Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions

A “foldamer” is an artificial oligomeric molecule with a regular secondary or tertiary structure consisting of various building blocks. A “stapled peptide” is a peptide with stabilized secondary structures, in particular, helical structures by intramolecular covalent side-chain cross-linking. Helica...

Full description

Saved in:
Bibliographic Details
Published in:Processes 2022-05, Vol.10 (5), p.924
Main Authors: Tsuchiya, Keisuke, Kurohara, Takashi, Fukuhara, Kiyoshi, Misawa, Takashi, Demizu, Yosuke
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Cell cycle
Chemistry
Crosslinking
Design
Drug delivery systems
Drug development
Drug discovery
Enzymes
HIV
Human immunodeficiency virus
Methods
Modulators
Nucleic acids
Peptides
Protein interaction
Protein structure
Protein-protein interactions
Proteins
R&D
Research & development
Structure
Tertiary structure
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A “foldamer” is an artificial oligomeric molecule with a regular secondary or tertiary structure consisting of various building blocks. A “stapled peptide” is a peptide with stabilized secondary structures, in particular, helical structures by intramolecular covalent side-chain cross-linking. Helical foldamers and stapled peptides are potential drug candidates that can target protein-protein interactions because they enable multipoint molecular recognition, which is difficult to achieve with low-molecular-weight compounds. This mini-review describes a variety of peptide-based foldamers and stapled peptides with a view to their applications in drug discovery, including our recent progress.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr10050924