Impact of IL-28B gene polymorphism on chronic hepatitis-C patients progression with diabetes and non-diabetes

BackgroundChronic hepatitis C (CHC) is a silent viral infection; however, elevated mortality and morbidity rates are noted in Egypt due to its adverse effects. The augmented incidence of diabetes in patients with viral C infection may be owing to glucose intolerance, high BMI, senility, and inherite...

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Bibliographic Details
Published in:Egyptian Journal of Medical Human Genetics 2022-02, Vol.23 (1), p.21-9
Main Authors: Ateya, Rehab M, Afifi, Samir A, Abd Al Monem, Nagla, Al-Karamany, Amira S, Bessar, Ahmed A, Rageh, Fatma, Ahmed, Samar S, Ghareeb, Dalia
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
CHC
Chronic infection
Diabetes
Diabetes mellitus (non-insulin dependent)
Fibrosis
Gene polymorphism
Genetic factors
Genotype & phenotype
Glucose tolerance
Hepatitis
Hepatitis C
IL-28B
Interferon
Intolerance
Morbidity
PCR–RFLP
Risk factors
T2DM
Viral infections
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Summary:BackgroundChronic hepatitis C (CHC) is a silent viral infection; however, elevated mortality and morbidity rates are noted in Egypt due to its adverse effects. The augmented incidence of diabetes in patients with viral C infection may be owing to glucose intolerance, high BMI, senility, and inherited factors.Purpose of the studyLittle information is available about the connection between interleukin-28B (IL-28B) genotype in disease progression among CHC patients with diabetes. Thus, we aimed to assess the association between IL-28B genotype (rs12979860) in CHC with type 2 diabetes mellitus (T2DM) versus those without diabetes in disease progression among Egyptian patients.ResultsCC genotype was significantly lower in diabetics than in non-diabetics (13.7% vs. 36.3%). While (CT/TT) were significantly higher in diabetics than in non-diabetics (CT 58.8% vs. 43.7%), (TT 27.5% vs. 20%) (p = 0.03) and likewise alleles (p = 0.04). Multivariate logistic regression analysis was significant with viral load p 
ISSN:1110-8630
2090-2441
DOI:10.1186/s43042-022-00239-3