MTHFR C677T genetic polymorphism is associated with development risk of essential hypertension in the Turkish population

Background Hypertension is a serious condition that is spread worldwide and may lead to severe complications such as heart attack, stroke, hypertensive retinopathy, and renal failure. Although some genetic and environmental risk factors are known to play a role in the etiology of hypertension, like...

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Bibliographic Details
Published in:Egyptian Journal of Medical Human Genetics 2022-01, Vol.23 (1), p.4-8
Main Authors: Er, Zafer Cengiz, Muderrisoglu, Ahmet, Ekim, Meral, Ekim, Hasan
Format: Article
Language:English
Subjects:
Alleles
Blood pressure
Coagulation factors
Development and progression
Essential hypertension
Ethylenediaminetetraacetic acid
Etiology
Factor V
FVL
Gene polymorphism
Genetic aspects
Genetic polymorphisms
Genetic research
Genotype & phenotype
Heart attack
Hypertension
Methylenetetrahydrofolate reductase
MTHFR
Myocardial infarction
Polymorphism
Prothrombin
Renal failure
Retinopathy
Risk factors
Thrombin
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Summary:Background Hypertension is a serious condition that is spread worldwide and may lead to severe complications such as heart attack, stroke, hypertensive retinopathy, and renal failure. Although some genetic and environmental risk factors are known to play a role in the etiology of hypertension, like most of the other multi-factorial diseases, its etiology is yet to be fully elucidated. Our study aimed to investigate the effects of methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and A1298C (rs1801131), factor V Leiden (FVL) G1691A (rs6025), and prothrombin (PT) G20210A (rs1799963) genetic polymorphisms on the development risk of essential hypertension and level of blood pressure in hypertensive patients. Results The frequency of the homozygous polymorphic TT genotype for the MTHFR C677T polymorphism was significantly higher in male hypertensive patients than in the male control group (27% vs 6.3%, p = 0.028). The rate of the variant T allele for the MTHFR C677T polymorphism was also significantly higher in male hypertensive patients compared to male healthy controls (51.4% vs 21.9%, p = 0.0004). There was no difference among hypertensive patients and healthy controls regarding the frequencies of MTHFR A1298C, FVL G1691A and PT G20210A polymorphisms. In addition, we found no difference between genotype groups regarding systolic and diastolic blood pressure levels in hypertensive patients. Conclusions Homozygous polymorphic TT genotype and variant T allele for the MTHFR C677T polymorphism may be considered as a risk factor for the development of essential hypertension in the Turkish male population.
ISSN:1110-8630
2090-2441
DOI:10.1186/s43042-022-00221-z