Effect of pH and temperature on swelling Behaviour of tamarind gum

Natural gum tamarind is a plant polysaccharide extracted from seeds endosperm of the plant, Tamarindus indica Linn. Thin film of the gum was prepared by direct compression method. The prepared film was investigated for the effect of pH and temperature on solvent uptake property of film by gravimetri...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-10, Vol.14 (10), p.5471-5474
Main Authors: Panda, Braja B., Sahoo, Rudra N., Nayak, Nilamadhab, Mallick, Subrata
Format: Article
Language:English
Subjects:
Conflicts of interest
Drug delivery systems
Equilibrium
Hydrogels
Kinetics
Laboratories
Pharmaceuticals
Physiology
Polymers
Seeds
Solvents
Thin films
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Summary:Natural gum tamarind is a plant polysaccharide extracted from seeds endosperm of the plant, Tamarindus indica Linn. Thin film of the gum was prepared by direct compression method. The prepared film was investigated for the effect of pH and temperature on solvent uptake property of film by gravimetric method. Different swelling parameters such as mass swelling ratio (MSR), equilibrium swelling ratio (ESR), equilibrium swelling ratio (ESw) and the equilibrium water content (EWC) were studied. It was found that swelling parameters were influenced by different pH and temperature conditions. The results suggested that the water content in equilibrium state was similar to body fluid. The gum converted to a high viscous gel of pseudo plastic characteristics in different pH conditions and the mechanism of continuous diffusion of solvent molecules into tablet during swelling was a non fickian and followed a second order kinetics.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.00954