Synthesis of some novel 1,3,4-oxadiazole derivatives and evaluation of their antimicrobial activity

Treatment for microbial infections still remains an important health problem for researchers around the world. Despite a broad range of antimicrobial drugs today, there are certain obstacles associated with the use of antimicrobial agents such as drug resistance and toxicity. Thus, medicinal chemist...

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Bibliographic Details
Published in:Synthetic communications 2022-03, Vol.52 (6), p.926-935
Main Authors: Tok, Fatih, Kaya, Murat, Karaca, Hülya, Koçyiğit-Kaymakçıoğlu, Bedia
Format: Article
Language:English
Subjects:
Antibacterial
antifungal
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Chemists
Chloromycetin
Drug resistance
Drugs
E coli
Gram-positive bacteria
infection
MIC
Microorganisms
oxadiazole
Oxadiazoles
Thermal stability
Toxicity
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Summary:Treatment for microbial infections still remains an important health problem for researchers around the world. Despite a broad range of antimicrobial drugs today, there are certain obstacles associated with the use of antimicrobial agents such as drug resistance and toxicity. Thus, medicinal chemists concentrate on designing novel antimicrobial drugs. In the search for new antimicrobial agents; 1,3,4-oxadiazole compounds have come forward due to their hydrolytic stability, good chemical and thermal stability. In the scope of this work, 2-(6-chloropyridin-3-yl)-5-(substitutedphenyl)-1,3,4-oxadiazole (4a-4i) were synthesizedusing 6-chloro-N'-(substitutedbenzoyl)nicotinohydrazide (3a-3i). These compounds were screened for their antimicrobial activities against as gram-positive bacteria S. aureus, E. faecalis, as gram-negative bacteria E. coli, P. aeruginosa, as yeast C. parapsilosis, C. albicans, C. glabrata. Among the 1,3,4-oxadiazole compounds, 4h against E. faecalis and 4b, 4f and 4g against E. coli have been found to exhibit as much as potency chloramphenicol with MIC 50 values of 62.50 µg/mL.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2022.2060751