Preparation,Characterization and Study of Biological Activity for some new derivatives Mannich's bases derived from Shiff's bases

This paper involves synthesis new Mannich bases derived from Shiff' bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to pr...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-11, Vol.14 (11), p.6025-6032
Main Authors: Sadiq Majeed, Nadia, Ali Saleh, Nada, AL-Baqi Aldujaili, Radhiyah Abd
Format: Article
Language:English
Subjects:
Antibiotics
Biological activity
Ethanol
Pharmaceutical sciences
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Summary:This paper involves synthesis new Mannich bases derived from Shiff' bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to produce Mannich bases derivatives (M1, G1, B1, R1, X1, S1). The third step included the assay of biological activity of all compounds against four types of pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and (E. coli, Proteus mirabilis) gram negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin) these structures were identified by FT-IR,1HNMRand 13CNMR.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.01047