Microwave Assisted Synthesis of Flavonoid Based 1,2,3-Triazole and Isoxazole Derivatives, Their Antibacterial, Antioxidant, and Anticancer Activities

New flavonoid based 1,2,3-triazole and isoxazole derivatives have been synthesized under microwave irradiation and conventional heating methods. Structures of the synthesized compounds have been confirmed by IR, 1 H and 13 C, and mass spectra. All products have been tested in vitro for antibacterial...

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Bibliographic Details
Published in:Russian journal of general chemistry 2022-04, Vol.92 (4), p.718-724
Main Authors: Ashok, Dongamanti, Thara, Gugulothu, Dharavath, Ravinder, Kirankumar, Bhukya, Sarasija, Madderla, Bhima, Bhukya
Format: Article
Language:English
Subjects:
Antibacterial agents
Anticancer properties
Antioxidants
Ascorbic acid
Bioflavonoids
Cancer
Care and treatment
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Doxorubicin
E coli
Escherichia coli
Flavones
Flavonoids
Mandatory drug testing
Mass spectra
Pseudomonas aeruginosa
Scavenging
Streptomycin
Synthesis
Triazoles
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Summary:New flavonoid based 1,2,3-triazole and isoxazole derivatives have been synthesized under microwave irradiation and conventional heating methods. Structures of the synthesized compounds have been confirmed by IR, 1 H and 13 C, and mass spectra. All products have been tested in vitro for antibacterial, antioxidant and anticancer activities . Several of these demonstrate high activity against gram positive pathogens Bacillus subtilis , Staphylococcus aureus and gram negative species Escherichia coli , Pseudomonas aeruginosa using streptomycin as a standard drug. Antioxidant radical scavenging activity of the products has been tested using ascorbic acid as a standard drug. Anticancer activity has been tested against MCF-7 and HeLa cell lines using doxorubicin as a standard drug. Two products have demonstrated promising results.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363222040132