Drug Release Stimulated by Magnetic Field and Light on Magnetite- and Carbon Dot-Loaded Carbon Nanohorn

Magnetite nanoparticles of 9 nm size were synthesized by co-precipitation, hybridized with carbon dots by in situ hydrothermal treatment, and chemically bound on an acid-treated carbon nanohorn through carbon dots. Separately, magnetite nanoparticles were in situ deposited on an acid-treated carbon...

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Japan 2022-04, Vol.95 (4), p.582-594
Main Authors: Su, Chin-Hao, Soendoro, Andree, Okayama, Shinya, Rahmania, Fitriani Jati, Nagai, Takashi, Imae, Toyoko, Tsutsumiuchi, Kaname, Kawai, Noriyasu
Format: Article
Language:English
Subjects:
Aqueous solutions
Carbon dots
Composite materials
Doxorubicin
Hydrothermal treatment
Hyperthermia
Light emission
Magnetite
Nanoparticles
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Summary:Magnetite nanoparticles of 9 nm size were synthesized by co-precipitation, hybridized with carbon dots by in situ hydrothermal treatment, and chemically bound on an acid-treated carbon nanohorn through carbon dots. Separately, magnetite nanoparticles were in situ deposited on an acid-treated carbon nanohorn. Both composites were well dispersed in aqueous medium and displayed magnetism. These composites were examined for drug (doxorubicin and gemcitabine) loading/release and, additionally, a carbon dot-immobilized composite exerted the influence of the photodynamic/photothermal effects under laser light emission on gemcitabine release. The release of gemcitabine from magnetite-bound composite was completed when the hyperthermia procedure was conducted together under a magnet. Thus, the magnetite- and carbon dot-including composites possess possible simultaneous usage in phototherapy and thermotherapy including hyperthermia beside chemotherapy.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20210436