N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products
Synthetic approaches to daunorubicin derivatives containing azide and propargyl fragments were developed. A series of phosphonate and bisphosphonate derivatives (including those containing P–C–P fragments) were obtained by the methods of click chemistry and by direct amidation. The obtained compound...
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Published in: | Medicinal chemistry research 2022-06, Vol.31 (6), p.1011-1025 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Synthetic approaches to daunorubicin derivatives containing azide and propargyl fragments were developed. A series of phosphonate and bisphosphonate derivatives (including those containing P–C–P fragments) were obtained by the methods of click chemistry and by direct amidation. The obtained compounds show small cytotoxicity not higher than that of parent daunorubicin.
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ISSN: | 1054-2523 1554-8120 |
DOI: | 10.1007/s00044-022-02889-9 |