Anti-inflammatory and cytotoxic chemical constituents from the trunks of Berberis wallichiana

The chemical compositions and biological activities of the Berberis wallichiana trunk were evaluated for the first time. The alkaloid berberine was found as the main constituent of this plant. In the essential oil fraction, safrole was the most abundant component. The isolated 8-oxypalmatine compoun...

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Bibliographic Details
Published in:Bioresources 2022-08, Vol.17 (3), p.4297-4305
Main Authors: Thanh, Bui Van, Anh, Nguyen Thi Van, Ha, Chu Thi Thu, Thuy, Dinh Thi Thu, Giang, Do Hoang, Dat, Nguyen Tien
Format: Article
Language:English
Subjects:
Alkaloids
Berberine
Berberis
Bioactive compounds
Breast cancer
Breast carcinoma
Cancer
Chemical composition
Chromatography
Constituents
Cytotoxicity
Essential oils
Experiments
Inflammation
Lung carcinoma
Mass spectrometry
Nitric oxide
NMR
Nuclear magnetic resonance
Oils & fats
Prostate carcinoma
Safrole
Scientific imaging
Sensors
Tumor cell lines
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Summary:The chemical compositions and biological activities of the Berberis wallichiana trunk were evaluated for the first time. The alkaloid berberine was found as the main constituent of this plant. In the essential oil fraction, safrole was the most abundant component. The isolated 8-oxypalmatine compound exhibited cytotoxic effects on all three cancer cell lines A549 (human lung carcinoma), MDA-MB-231 (human breast carcinoma), and DU145 (human prostate carcinoma), while berberine was the most active to DU145 cells (IC50 of 4.99 μM). This alkaloid compound also potently inhibited the production of nitric oxide with IC50 at 0.017 μM. These findings suggested that the trunks of B. wallichiana might be a good source of bioactive compounds.
ISSN:1930-2126
1930-2126
DOI:10.15376/biores.17.3.4297-4305