Reactions of N-Benzyl- and N-(2-Phenylethyl)maleimides with Secondary Amines

It was found that the reactions of N -benzylmaleimide with secondary amines proceed at the double C=C bond and lead to the formation of 3- N , N -R 2 -aminosubstituted succinimides. In the case of N -phenethylmaleimide, the nucleophilic addition of secondary amines is accompanied by an amidation rea...

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Bibliographic Details
Published in:Russian journal of general chemistry 2022-05, Vol.92 (5), p.745-749
Main Authors: Kolyamshin, O. A., Mitrasov, Yu. N., Danilov, V. A., Avruyskaya, A. A., Pylchikova, Yu. Yu
Format: Article
Language:English
Subjects:
Amines
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Maleic acid
Nitrogen
Olefins
Ring opening
Succinimides
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Summary:It was found that the reactions of N -benzylmaleimide with secondary amines proceed at the double C=C bond and lead to the formation of 3- N , N -R 2 -aminosubstituted succinimides. In the case of N -phenethylmaleimide, the nucleophilic addition of secondary amines is accompanied by an amidation reaction, which proceeds with ring opening and leads to the formation of unsymmetrical maleic acid diamides.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363222050012