Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants

After two doses of mRNA vaccine, health care workers had less viral neutralizing-antibody activity against the BA.4/5 and BA.2.12.1 omicron subvariants than against the BA.1 and BA.2 subvariants, but titers increased significantly with a booster dose.

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Bibliographic Details
Published in:New England Journal of Medicine 2022-06
Main Authors: Qu, Panke, Faraone, Julia, Evans, John P, Zou, Xue, Yi-Min, Zheng, Carlin, Claire, Bednash, Joseph S, Lozanski, Gerard, Mallampalli, Rama K, Saif, Linda J, Oltz, Eugene M, Mohler, Peter J, Gumina, Richard J, Shan-Lu, Liu
Format: Article
Language:English
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Summary:After two doses of mRNA vaccine, health care workers had less viral neutralizing-antibody activity against the BA.4/5 and BA.2.12.1 omicron subvariants than against the BA.1 and BA.2 subvariants, but titers increased significantly with a booster dose.
DOI:10.1056/NEJMc2206725