Understanding and management of anti-N-methyl-D-aspartate receptor encephalitis from a child psychiatry perspective: report of five cases

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a rare autoimmune entity in psychiatry literature that occurs when antibodies attack NMDA-type glutamate receptors in the brain. Principle clinical features include a neurological domain such as seizure, orofacial dyskinesia, dystonia,...

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Bibliographic Details
Published in:Neurocase 2022-04, Vol.28 (2), p.239-245
Main Authors: Dogan, Nurhak, Subasi, Hilal, Erbasan, Zeynep Irem, Tahillioglu, Akin, Kanmaz, Seda, Kose, Sezen, Ozbaran, Burcu, Serin, Hepsen Mine
Format: Article
Language:English
Subjects:
acute psychosis
Affective disorders
Anti-NMDA receptor
Child & adolescent psychiatry
depression
Dystonia
Encephalitis
Glutamic acid receptors
Glutamic acid receptors (ionotropic)
limbic encephalitis
N-Methyl-D-aspartic acid receptors
neuropsychiatric disorders
Seizures
Tardive dyskinesia
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Summary:Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a rare autoimmune entity in psychiatry literature that occurs when antibodies attack NMDA-type glutamate receptors in the brain. Principle clinical features include a neurological domain such as seizure, orofacial dyskinesia, dystonia, and choreic-like movements of extremities. Also the psychiatric manifestations of this form of encephalitis may vary from psychotic-like symptoms to mood symptoms like depression or mania. Herein we report on five female child cases diagnosed with anti-NMDAR encephalitis, presented with both neurological and psychiatric clinical picture, and highlight the trajectory of disorder from a psychiatric perspective.
ISSN:1355-4794
1465-3656
1362-4970
DOI:10.1080/13554794.2022.2086468