Plasma concentration of thyroid hormones and corticosterone in hypothyroid rats and its correction with synthetic enkephalin

The aim of the research is to study the possibility of correcting hypothyroidism with a synthetic analogue of the opioid leu-enkephalin (dalargin). The research was carried out on 70 white outbred male rats. The animals were simulated experimental hypothyroidism by the introduction of a synthetic th...

Full description

Saved in:
Bibliographic Details
Main Authors: Garmaeva, D. V., Adushinov, D. S., Kuznetsov, A. I., Mirvaliyev, F. S.
Format: Conference Proceeding
Language:English
Subjects:
Hormones
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the research is to study the possibility of correcting hypothyroidism with a synthetic analogue of the opioid leu-enkephalin (dalargin). The research was carried out on 70 white outbred male rats. The animals were simulated experimental hypothyroidism by the introduction of a synthetic thyreostatic which is called mercazolil. The positive long-term corrective effect of dalargin on the production of thyroid hormones has been shown. Dalargin lowers corticosterone level and protects the body from the damaging effects of stress.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0093895