Uranium chelating ability of decorporation agents in serum evaluated by X-ray absorption spectroscopy

Internal exposure to actinides such as uranium and plutonium has been reduced using chelating agents for decorporation because of their potential to induce both radiological and chemical toxicities. This study measures uranium chemical forms in serum in the presence and absence of chelating agents b...

Full description

Saved in:
Bibliographic Details
Published in:Analytical methods 2022-06, Vol.14 (24), p.2439-2445
Main Authors: Uehara, Akihiro, Matsumura, Daiju, Tsuji, Takuya, Yakumaru, Haruko, Tanaka, Izumi, Shiro, Ayumi, Saitoh, Hiroyuki, Ishihara, Hiroshi, Homma-Takeda, Shino
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Actinides
Chelating agents
Chelation
Deferoxamine
Evaluation
Inositol
Inositols
Ligands
Plutonium
Principal components analysis
Spectrum analysis
Toxicity
Uranium
X ray absorption
X-ray absorption spectroscopy
X-ray spectroscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Internal exposure to actinides such as uranium and plutonium has been reduced using chelating agents for decorporation because of their potential to induce both radiological and chemical toxicities. This study measures uranium chemical forms in serum in the presence and absence of chelating agents based on X-ray absorption spectroscopy (XAS). The chelating agents used were 1-hydroxyethane 1,1-bisphosphonate (EHBP), inositol hexaphosphate (IP6), deferoxamine B (DFO), and diethylenetriaminepentaacetate (DTPA). Percentages of uranium-chelating agents and uranium-bioligands (bioligands: inorganic and organic ligands coordinating with uranium) dissolving in the serum were successfully evaluated based on principal component analysis of XAS spectra. The main ligands forming complexes with uranium in the serum were estimated as follows: IP6 > EHBP > bioligands > DFO > DTPA when the concentration ratio of the chelating agent to uranium was 10. Measurements of uranium chemical forms and their concentrations in the serum would be useful for the appropriate treatment using chelating agents for the decorporation of uranium. Internal exposure to actinides such as uranium and plutonium has been reduced using chelating agents for decorporation because of their potential to induce both radiological and chemical toxicities.
ISSN:1759-9660
1759-9679
DOI:10.1039/d2ay00565d