Influence of zinc and gallic acid on haematological alterations, hepatic and intestinal toxicity induced by sub-acute exposure to Dibutyl-n-phthalate (DBP) in Wistar rats

• Published in: Toxicology and environmental health sciences 2022-06, Vol.14 (2), p.203-212
• Main Authors: Akinrinde, Akinleye Stephen, Bello, Asabe Vivian, Soetan, Kehinde Olugboyega
• Format: Article
• Language: English
• Subjects: Alanine; Atrophy; Biomedical and Life Sciences; Biomedicine; Coliforms; Consumer products; Dietary supplements; E coli; Environmental Health; Erythrocytes; Escherichia coli; Fecal coliforms; Food processing; Gallic acid; Hematology; Hepatocytes; Inflammation; Intestine; Liver; Mucosa; Mucus; Original Article; Pharmacology/Toxicology; Phthalates; Preservation; Probiotics; Reduction; Toxicity; Zinc
• ISSN: 2005-9752; 2233-7784
• DOI: 10.1007/s13530-022-00130-z

Objective Dibutyl- n -phthalate (DBP) is utilized industrially as a plasticizer, as well as in consumer products, food processing and medical applications, but there are concerns over its safety. This study investigated the protective effect of Zinc sulphate (Zn) and Gallic acid (GA) against haematological, hepatic and intestinal alterations following sub-acute (14-day) DBP exposure in rats. Methods Twenty-four male Wistar rats weighing 150–190 g were randomly allocated into 4 groups ( n  = 6). Group A (Control) received normal saline at 2 ml/kg. Group B was given DBP (500 mg/kg bw/day) by oral gavage for 14 days. Groups C and D were treated concurrently with Zn (250 mg/kg bw) and GA (120 mg/kg bw), respectively, in addition to DBP treatment. Results Administration of DBP resulted in significant ( p