TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation?

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with an unmet therapeutic need. Fibrotic remodeling, in which collagen-producing atrial fibroblasts play a crucial role, substantially contributes to arrhythmia promotion and progression. In this issue of the JCI, Lai, Tsai, a...

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Bibliographic Details
Published in:The Journal of clinical investigation 2022-07, Vol.132 (13), p.1-4
Main Authors: Saljic, Arnela, Grandi, Eleonora, Dobrev, Dobromir
Format: Article
Language:English
Subjects:
Arrhythmia
Biomedical research
Cardiac arrhythmia
Cardiomyocytes
Cardiovascular disease
Collagen
Fibrillation
Fibroblasts
Fibrosis
Heart
Kinases
Mesenchyme
Therapeutic targets
Transforming growth factor-b1
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Summary:Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with an unmet therapeutic need. Fibrotic remodeling, in which collagen-producing atrial fibroblasts play a crucial role, substantially contributes to arrhythmia promotion and progression. In this issue of the JCI, Lai, Tsai, and co-authors reveal that TGF-ß1 promoted endothelial-mesenchymal transition during AF and put forward the notion that, in the adult heart, atrial fibroblasts can originate from different cellular sources. These important findings extend our understanding of the origin, biology, and function of fibroblasts and offer possibilities for therapeutic targeting of fibrosis in AF.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI142548