Direct Asymmetric Addition of Heteroatom Nucleophiles to Imines

The direct asymmetric addition of heteroatom nucleophiles to imines represents one of the most efficient tools for the formation of carbon‐heteroatom bonds and has received much interest recently. The review is devoted to the asymmetric addition reactions of non‐carbon nucleophiles to imines. The pr...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2022-07, Vol.364 (13), p.2092-2112
Main Authors: Egorov, Ilya N., Santra, Sougata, Zyryanov, Grigory V., Majee, Adinath, Hajra, Alakananda, Chupakhin, Oleg N.
Format: Article
Language:English
Subjects:
Asymmetric addition
Asymmetric synthesis
Asymmetry
Carbon
Chiral catalysts
Heteroatom nucleophiles
Imines
Kabachnik-Fields reactions
Lewis acid
Nucleophiles
Phosphoric acid
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Summary:The direct asymmetric addition of heteroatom nucleophiles to imines represents one of the most efficient tools for the formation of carbon‐heteroatom bonds and has received much interest recently. The review is devoted to the asymmetric addition reactions of non‐carbon nucleophiles to imines. The present review is divided into five main sections: reactions with N‐nucleophiles; reactions with P‐nucleophiles; reactions with O‐nucleophiles; reactions with S‐nucleophiles; reactions with Se‐nucleophiles. It has been seen that chiral catalysts such as quinines, BINOLs, chiral phosphoric acids as well as various Brønsted and Lewis acids are the source of asymmetry of the presented reactions of asymmetric addition of non‐carbon nucleophiles to imines.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202200155