WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus

• Published in: International journal of diabetes in developing countries 2022-04, Vol.42 (2), p.269-275
• Main Authors: Liu, Li-chao, Xu, Shi-ting, Li, Ling
• Format: Article
• Language: English
• Subjects: Abdomen; Adipose tissue; Alanine; Alanine transaminase; Body fat; Body mass index; Carbohydrate metabolism; Cesarean section; Diabetes; Diabetes mellitus; Family Medicine; Fasting; Gene expression; General Practice; Gestational diabetes; Glucose; Glucose tolerance; Health Administration; Insulin; Insulin resistance; Interleukin 6; Lipid metabolism; Medicine; Medicine & Public Health; Metabolism; Original Article; Placenta; Polymerase chain reaction; Reverse transcription; Signal transduction; Thyroid; Wnt protein
• ISSN: 0973-3930; 1998-3832
• DOI: 10.1007/s13410-021-00972-2

Objective This study aimed to investigate the concentration of Wingless-type (Wnt)-inducible signaling pathway protein-1 (WISP1) in the serum, and its expression in the abdominal subcutaneous adipose tissue (SAT), and placenta of women with gestational diabetes mellitus (GDM). Methods A total of 69 patients with GDM and 71 pregnant women with normal glucose tolerance (NGT, control) were recruited. Carbohydrate metabolism, alanine aminotransferase (ALT), lipid profiles, thyroid function, interleukin-6 (IL-6), and WISP1 levels were assessed. Fasting sera were collected between 25 and 30 weeks of gestation. Tissues of placenta and abdominal SAT samples were obtained from 24 women who had undergone cesarean section and were divided into a GDM group and a control group. Reverse transcription polymerase chain reaction (RT-PCR) and western blot were used to detect the WISP1 expression. Results The serum WISP1 concentrations were higher in the GDM group than in the control group ( p