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WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus
Objective This study aimed to investigate the concentration of Wingless-type (Wnt)-inducible signaling pathway protein-1 (WISP1) in the serum, and its expression in the abdominal subcutaneous adipose tissue (SAT), and placenta of women with gestational diabetes mellitus (GDM). Methods A total of 69...
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| Published in: | International journal of diabetes in developing countries 2022-04, Vol.42 (2), p.269-275 |
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| container_end_page | 275 |
| container_issue | 2 |
| container_start_page | 269 |
| container_title | International journal of diabetes in developing countries |
| container_volume | 42 |
| creator | Liu, Li-chao Xu, Shi-ting Li, Ling |
| description | Objective
This study aimed to investigate the concentration of Wingless-type (Wnt)-inducible signaling pathway protein-1 (WISP1) in the serum, and its expression in the abdominal subcutaneous adipose tissue (SAT), and placenta of women with gestational diabetes mellitus (GDM).
Methods
A total of 69 patients with GDM and 71 pregnant women with normal glucose tolerance (NGT, control) were recruited. Carbohydrate metabolism, alanine aminotransferase (ALT), lipid profiles, thyroid function, interleukin-6 (IL-6), and WISP1 levels were assessed. Fasting sera were collected between 25 and 30 weeks of gestation. Tissues of placenta and abdominal SAT samples were obtained from 24 women who had undergone cesarean section and were divided into a GDM group and a control group. Reverse transcription polymerase chain reaction (RT-PCR) and western blot were used to detect the WISP1 expression.
Results
The serum WISP1 concentrations were higher in the GDM group than in the control group (
p
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| doi_str_mv | 10.1007/s13410-021-00972-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2685063385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2685063385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-528090f3b7ee3be1170e6db4fb1559931e3749f8a70ff4f724f5e0cdd977c9d93</originalsourceid><addsrcrecordid>eNp9kFtLxDAQhYMouK7-AZ8CvlqdJO2meRTxBoKCio8hbSdull7WTMriv7frCr75NBfOd5g5jJ0KuBAA-pKEygVkIEUGYLTM5B6bCWPKTJVK7rPZtFSZMgoO2RHRCqAo5ELNWHx_eHkWPBAPfR3RETZTx9MSeecSxt61nDCO3Tl3TVgPhDwFohGnuW_4unU19snxwfPN0GHPNyEt-QdScikMW7oJrsKExDts25BGOmYH3rWEJ791zt5ub16v77PHp7uH66vHrFbCpKyQJRjwqtKIqkIhNOCiqXJfiaIwRglUOje-dBq8z72WuS8Q6qYxWtemMWrOzna-6zh8jtNFdjWM24fIykVZwEKpsphUcqeq40AU0dt1DJ2LX1aA3WZrd9naKVv7k62VE6R2EE3i_gPjn_U_1Df1Sn0L</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2685063385</pqid></control><display><type>article</type><title>WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus</title><source>Springer Nature</source><creator>Liu, Li-chao ; Xu, Shi-ting ; Li, Ling</creator><creatorcontrib>Liu, Li-chao ; Xu, Shi-ting ; Li, Ling</creatorcontrib><description>Objective
This study aimed to investigate the concentration of Wingless-type (Wnt)-inducible signaling pathway protein-1 (WISP1) in the serum, and its expression in the abdominal subcutaneous adipose tissue (SAT), and placenta of women with gestational diabetes mellitus (GDM).
Methods
A total of 69 patients with GDM and 71 pregnant women with normal glucose tolerance (NGT, control) were recruited. Carbohydrate metabolism, alanine aminotransferase (ALT), lipid profiles, thyroid function, interleukin-6 (IL-6), and WISP1 levels were assessed. Fasting sera were collected between 25 and 30 weeks of gestation. Tissues of placenta and abdominal SAT samples were obtained from 24 women who had undergone cesarean section and were divided into a GDM group and a control group. Reverse transcription polymerase chain reaction (RT-PCR) and western blot were used to detect the WISP1 expression.
Results
The serum WISP1 concentrations were higher in the GDM group than in the control group (
p
< 0.01) and positively associated with body mass index (BMI), fasting glucose, fasting insulin, HOMA-insulin resistance (HOMA-IR), and IL-6 levels. BMI, fasting glucose, and HOMA-IR independently and positively predicted WISP1 levels. Further, WISP1 mRNA and protein expression were higher in tissues from the placenta and abdominal SAT from the GDM group (
p
< 0.01).
Conclusions
WISP1 may be an important adipokine in modulating carbohydrate metabolism in women with GDM.</description><identifier>ISSN: 0973-3930</identifier><identifier>EISSN: 1998-3832</identifier><identifier>DOI: 10.1007/s13410-021-00972-2</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Abdomen ; Adipose tissue ; Alanine ; Alanine transaminase ; Body fat ; Body mass index ; Carbohydrate metabolism ; Cesarean section ; Diabetes ; Diabetes mellitus ; Family Medicine ; Fasting ; Gene expression ; General Practice ; Gestational diabetes ; Glucose ; Glucose tolerance ; Health Administration ; Insulin ; Insulin resistance ; Interleukin 6 ; Lipid metabolism ; Medicine ; Medicine & Public Health ; Metabolism ; Original Article ; Placenta ; Polymerase chain reaction ; Reverse transcription ; Signal transduction ; Thyroid ; Wnt protein</subject><ispartof>International journal of diabetes in developing countries, 2022-04, Vol.42 (2), p.269-275</ispartof><rights>Research Society for Study of Diabetes in India 2021</rights><rights>Research Society for Study of Diabetes in India 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-528090f3b7ee3be1170e6db4fb1559931e3749f8a70ff4f724f5e0cdd977c9d93</citedby><cites>FETCH-LOGICAL-c319t-528090f3b7ee3be1170e6db4fb1559931e3749f8a70ff4f724f5e0cdd977c9d93</cites><orcidid>0000-0002-1940-8693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Liu, Li-chao</creatorcontrib><creatorcontrib>Xu, Shi-ting</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><title>WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus</title><title>International journal of diabetes in developing countries</title><addtitle>Int J Diabetes Dev Ctries</addtitle><description>Objective
This study aimed to investigate the concentration of Wingless-type (Wnt)-inducible signaling pathway protein-1 (WISP1) in the serum, and its expression in the abdominal subcutaneous adipose tissue (SAT), and placenta of women with gestational diabetes mellitus (GDM).
Methods
A total of 69 patients with GDM and 71 pregnant women with normal glucose tolerance (NGT, control) were recruited. Carbohydrate metabolism, alanine aminotransferase (ALT), lipid profiles, thyroid function, interleukin-6 (IL-6), and WISP1 levels were assessed. Fasting sera were collected between 25 and 30 weeks of gestation. Tissues of placenta and abdominal SAT samples were obtained from 24 women who had undergone cesarean section and were divided into a GDM group and a control group. Reverse transcription polymerase chain reaction (RT-PCR) and western blot were used to detect the WISP1 expression.
Results
The serum WISP1 concentrations were higher in the GDM group than in the control group (
p
< 0.01) and positively associated with body mass index (BMI), fasting glucose, fasting insulin, HOMA-insulin resistance (HOMA-IR), and IL-6 levels. BMI, fasting glucose, and HOMA-IR independently and positively predicted WISP1 levels. Further, WISP1 mRNA and protein expression were higher in tissues from the placenta and abdominal SAT from the GDM group (
p
< 0.01).
Conclusions
WISP1 may be an important adipokine in modulating carbohydrate metabolism in women with GDM.</description><subject>Abdomen</subject><subject>Adipose tissue</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Carbohydrate metabolism</subject><subject>Cesarean section</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Family Medicine</subject><subject>Fasting</subject><subject>Gene expression</subject><subject>General Practice</subject><subject>Gestational diabetes</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Health Administration</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Interleukin 6</subject><subject>Lipid metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Original Article</subject><subject>Placenta</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>Signal transduction</subject><subject>Thyroid</subject><subject>Wnt protein</subject><issn>0973-3930</issn><issn>1998-3832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kFtLxDAQhYMouK7-AZ8CvlqdJO2meRTxBoKCio8hbSdull7WTMriv7frCr75NBfOd5g5jJ0KuBAA-pKEygVkIEUGYLTM5B6bCWPKTJVK7rPZtFSZMgoO2RHRCqAo5ELNWHx_eHkWPBAPfR3RETZTx9MSeecSxt61nDCO3Tl3TVgPhDwFohGnuW_4unU19snxwfPN0GHPNyEt-QdScikMW7oJrsKExDts25BGOmYH3rWEJ791zt5ub16v77PHp7uH66vHrFbCpKyQJRjwqtKIqkIhNOCiqXJfiaIwRglUOje-dBq8z72WuS8Q6qYxWtemMWrOzna-6zh8jtNFdjWM24fIykVZwEKpsphUcqeq40AU0dt1DJ2LX1aA3WZrd9naKVv7k62VE6R2EE3i_gPjn_U_1Df1Sn0L</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Liu, Li-chao</creator><creator>Xu, Shi-ting</creator><creator>Li, Ling</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-1940-8693</orcidid></search><sort><creationdate>20220401</creationdate><title>WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus</title><author>Liu, Li-chao ; Xu, Shi-ting ; Li, Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-528090f3b7ee3be1170e6db4fb1559931e3749f8a70ff4f724f5e0cdd977c9d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdomen</topic><topic>Adipose tissue</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Carbohydrate metabolism</topic><topic>Cesarean section</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Family Medicine</topic><topic>Fasting</topic><topic>Gene expression</topic><topic>General Practice</topic><topic>Gestational diabetes</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Health Administration</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Interleukin 6</topic><topic>Lipid metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Original Article</topic><topic>Placenta</topic><topic>Polymerase chain reaction</topic><topic>Reverse transcription</topic><topic>Signal transduction</topic><topic>Thyroid</topic><topic>Wnt protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Li-chao</creatorcontrib><creatorcontrib>Xu, Shi-ting</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>International journal of diabetes in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Li-chao</au><au>Xu, Shi-ting</au><au>Li, Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus</atitle><jtitle>International journal of diabetes in developing countries</jtitle><stitle>Int J Diabetes Dev Ctries</stitle><date>2022-04-01</date><risdate>2022</risdate><volume>42</volume><issue>2</issue><spage>269</spage><epage>275</epage><pages>269-275</pages><issn>0973-3930</issn><eissn>1998-3832</eissn><abstract>Objective
This study aimed to investigate the concentration of Wingless-type (Wnt)-inducible signaling pathway protein-1 (WISP1) in the serum, and its expression in the abdominal subcutaneous adipose tissue (SAT), and placenta of women with gestational diabetes mellitus (GDM).
Methods
A total of 69 patients with GDM and 71 pregnant women with normal glucose tolerance (NGT, control) were recruited. Carbohydrate metabolism, alanine aminotransferase (ALT), lipid profiles, thyroid function, interleukin-6 (IL-6), and WISP1 levels were assessed. Fasting sera were collected between 25 and 30 weeks of gestation. Tissues of placenta and abdominal SAT samples were obtained from 24 women who had undergone cesarean section and were divided into a GDM group and a control group. Reverse transcription polymerase chain reaction (RT-PCR) and western blot were used to detect the WISP1 expression.
Results
The serum WISP1 concentrations were higher in the GDM group than in the control group (
p
< 0.01) and positively associated with body mass index (BMI), fasting glucose, fasting insulin, HOMA-insulin resistance (HOMA-IR), and IL-6 levels. BMI, fasting glucose, and HOMA-IR independently and positively predicted WISP1 levels. Further, WISP1 mRNA and protein expression were higher in tissues from the placenta and abdominal SAT from the GDM group (
p
< 0.01).
Conclusions
WISP1 may be an important adipokine in modulating carbohydrate metabolism in women with GDM.</abstract><cop>New Delhi</cop><pub>Springer India</pub><doi>10.1007/s13410-021-00972-2</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1940-8693</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0973-3930 |
| ispartof | International journal of diabetes in developing countries, 2022-04, Vol.42 (2), p.269-275 |
| issn | 0973-3930 1998-3832 |
| language | eng |
| recordid | cdi_proquest_journals_2685063385 |
| source | Springer Nature |
| subjects | Abdomen Adipose tissue Alanine Alanine transaminase Body fat Body mass index Carbohydrate metabolism Cesarean section Diabetes Diabetes mellitus Family Medicine Fasting Gene expression General Practice Gestational diabetes Glucose Glucose tolerance Health Administration Insulin Insulin resistance Interleukin 6 Lipid metabolism Medicine Medicine & Public Health Metabolism Original Article Placenta Polymerase chain reaction Reverse transcription Signal transduction Thyroid Wnt protein |
| title | WISP1 is increased in the maternal serum, adipose tissue, and placenta of women with gestational diabetes mellitus |
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