Modification of Sesquiterpene Lactones—Dehydrocostus Lactone and Alantolactone—by Click Chemistry Method. Cytotoxic Activity of the Obtained Conjugates

A method for modifying sesquiterpene lactones using the click chemistry methodology has been developed. A series of conjugates of alantolactone and dehydrocostus lactone with alkoxy substituted benzylazides was obtained and their cytotoxic profile with respect to tumor cells of the A549, SH-SY5Y, He...

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Bibliographic Details
Published in:Russian journal of general chemistry 2022-06, Vol.92 (6), p.960-968
Main Authors: Artyushin, O. I., Sharova, E. V., Nikolaeva, N. S., Aleksandrova, Yu. R., Semakov, A. V., Neganova, M. E., Brel, V. K.
Format: Article
Language:English
Subjects:
Chemical activity
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Conjugates
Lactones
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Summary:A method for modifying sesquiterpene lactones using the click chemistry methodology has been developed. A series of conjugates of alantolactone and dehydrocostus lactone with alkoxy substituted benzylazides was obtained and their cytotoxic profile with respect to tumor cells of the A549, SH-SY5Y, Hep-2 and HeLa lines was evaluated. It has been shown that derivatives containing dehydrocostus lactone motif in their structure exhibit the highest cytotoxic activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036322206007X