Bioactive Terpenoid from the Fruits of Lagerstroemia speciosa and its Molecular Docking Study

Bioactive terpenoids 1 and 2 along with a known compound, β -sitosterol, have been isolated from the DCM extract of the fruits of Lagerstroemia speciosa . Structures of 1 and 2 have been established by spectroscopic analysis. In vitro antibacterial and antifungal activity of 1 and 2 have been report...

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Bibliographic Details
Published in:Chemistry of natural compounds 2022-05, Vol.58 (3), p.485-490
Main Authors: Rabi, Saswata, Islam, Md. Nazrul, Islam, Md. Din, Sutradhar, Ranajit K.
Format: Article
Language:English
Subjects:
Biological activity
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fruit
Fruits
Fungicides
Molecular docking
Organic Chemistry
Plant Sciences
Protein binding
Terpenes
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Summary:Bioactive terpenoids 1 and 2 along with a known compound, β -sitosterol, have been isolated from the DCM extract of the fruits of Lagerstroemia speciosa . Structures of 1 and 2 have been established by spectroscopic analysis. In vitro antibacterial and antifungal activity of 1 and 2 have been reported. Compound 1 showed poor activity, but compound 2 exhibited significant antibacterial and antifungal activities. Molecular docking study of 2 also showed a good docking score within the binding pocket of the selected proteins.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-022-03716-8