Cocrystals of betulin with adipic acid: preparation and thermal behavior

The cocrystal of betulin (BE) with adipic acid (AA) was prepared using a liquid-assisted grinding method. The formation of BE-AA cocrystal was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. It was assumed that 1:1 BE-AA cocrystal hydrate was formed when liquid-a...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2022-08, Vol.147 (15), p.8235-8242
Main Authors: Myz, S. A., Mikhailenko, M. A., Mikhailovskaya, A. V., Bulina, N. V., Gerasimov, K. B., Politov, A. A., Kuznetsova, S. A., Shakhtshneider, T. P.
Format: Article
Language:English
Subjects:
Adipic acid
Analysis
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Diffraction
Grinding
Heating
Infrared spectroscopy
Inorganic Chemistry
Measurement Science and Instrumentation
Phase transitions
Physical Chemistry
Polymer Sciences
Relative humidity
Room temperature
Thermal analysis
Thermodynamic properties
Water chemistry
X ray powder diffraction
X-rays
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Summary:The cocrystal of betulin (BE) with adipic acid (AA) was prepared using a liquid-assisted grinding method. The formation of BE-AA cocrystal was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. It was assumed that 1:1 BE-AA cocrystal hydrate was formed when liquid-assisted grinding was carried out using water-miscible liquids in which the solubility of adipic acid was higher than in others. The cocrystal hydrate was stable under room temperature and rather high relative humidity. Nevertheless, the betulin–adipic acid cocrystal was found to decompose under heating after the loss of water molecules, followed by phase transformation. An anhydrous BE-AA cocrystal was also prepared by the BE-AA physical mixture heating up to the point of adipic acid melting.
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-021-11107-4