Maltol as a Novel Agent Protecting SH-SY5Y Cells Against Hemin-induced Ferroptosis

Ferroptosis triggered by hemin is regarded as a primary factor accounting for neuronal death secondary to intracerebral hemorrhage. Thus, compounds with inhibitory effect on hemin-induced ferroptosis might be potential medicines to prevent neuronal death caused by intracerebral hemorrhage. Herein, w...

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Bibliographic Details
Published in:Chemical research in Chinese universities 2022-08, Vol.38 (4), p.1089-1096
Main Authors: Hua, Cong, Wang, Xuanzhong, Liang, Shipeng, Li, Chen, Chen, Xi, Piao, Meihua, Wang, Zhenchuan, Ge, Pengfei, Luo, Tianfei
Format: Article
Language:English
Subjects:
Analytical Chemistry
Catalase
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hemorrhage
Hydrogen peroxide
Inorganic Chemistry
Lipids
Organic Chemistry
Physical Chemistry
Transferrin
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Summary:Ferroptosis triggered by hemin is regarded as a primary factor accounting for neuronal death secondary to intracerebral hemorrhage. Thus, compounds with inhibitory effect on hemin-induced ferroptosis might be potential medicines to prevent neuronal death caused by intracerebral hemorrhage. Herein, we investigate whether maltol could alleviate hemin-induced SH-SY5Y cell ferroptosis and its potential mechanisms. It is found that maltol effectively prevents hemin-induced SH-SY5Y cell ferroptosis via three pathways. The first one is inhibiting intracellular iron increase via preventing upregulation of transferrin receptor, the second one is alleviating lipid peroxidation via attenuating H 2 O 2 generation by NOX4 and promoting H 2 O 2 clearance by catalase, and the third one is to reduce peroxidized lipids via maintaining GPX4/GSH pathway. Therefore, maltol is a novel agent preventing hemin-induced SH-SY5Y cell ferroptosis.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-021-1438-2