Non-visualisation of fetal gallbladder in a Chinese cohort

Introduction: Non-visualisation of fetal gallbladder (NVFGB) is associated with chromosomal abnormalities, biliary atresia, cystic fibrosis, and gallbladder agenesis in Caucasian fetuses. We investigated the outcomes of fetuses with NVFGB in a Chinese cohort. Methods: This retrospective analysis inc...

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Published in:Hong Kong medical journal = Xianggang yi xue za zhi 2022-04, Vol.28 (2), p.116
Main Authors: Ting, Y H, So, P L, Cheung, K W, Lo, T K, Ma, Teresa WL, Leung, TY
Format: Article
Language:chi ; eng
Subjects:
Amniocentesis
Autopsies
Cystic fibrosis
Cysts
Fetuses
Gallbladder
Gestational age
Gynecology
Morphology
Obstetrics
Pregnancy
Prenatal care
Systematic review
Ultrasonic imaging
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Summary:Introduction: Non-visualisation of fetal gallbladder (NVFGB) is associated with chromosomal abnormalities, biliary atresia, cystic fibrosis, and gallbladder agenesis in Caucasian fetuses. We investigated the outcomes of fetuses with NVFGB in a Chinese cohort. Methods: This retrospective analysis included cases of NVFGB among Chinese pregnant women at five public fetal medicine clinics in Hong Kong from 2012 to 2019. We compared the incidences of subsequent gallbladder visualisation, chromosomal abnormalities, biliary atresia, cystic fibrosis, and gallbladder agenesis between cases of isolated NVFGB and cases of non-isolated NVFGB. Results: Among 19 cases of NVFGB detected at a median gestational age of 21.3 weeks (interquartile range, 20.0-22.3 weeks), 10 (52.6%) were isolated and nine (47.4%) were non-isolated. Eleven (58.0%) cases had transient non-visualisation, four (21.0%) had gallbladder agenesis, three (15.8%) had chromosomal abnormalities (trisomy 18, trisomy 21, and 22q11.2 microduplication), one (5.
ISSN:1024-2708
2226-8707
DOI:10.12809/hkmj208938