Comparing outcomes of clonidine and captopril in patients with hypertensive urgency: A randomized clinical trial

An important situation in patients with high BP is hypertensive crisis (BP > 180/120 mmHg), which is divided to hypertensive emergency and urgency. [...]here, we decided to compare the effect of captopril and clonidine in patients with hypertensive urgencies, and their side effects. Regarding the...

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Bibliographic Details
Published in:ARYA atherosclerosis 2022-01, Vol.18, p.1-6
Main Authors: Mirdamadi, Ahmad, Abrishamkar, Rana, Kargaran, Afrooz
Format: Article
Language:English
Subjects:
Antihypertensives
Blood pressure
Clinical trials
Drug dosages
Headaches
Hypertension
Intervention
Patients
Pharmaceuticals
Software
Vertigo
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Summary:An important situation in patients with high BP is hypertensive crisis (BP > 180/120 mmHg), which is divided to hypertensive emergency and urgency. [...]here, we decided to compare the effect of captopril and clonidine in patients with hypertensive urgencies, and their side effects. Regarding the duration of response to treatment drugs, patients who received clonidine relieved significantly faster than those who received captopril (P = 0.016). [...]the frequencies of side effects such as headache, dizziness/vertigo, dry mouth, and drowsiness in the clonidine group were significantly lower than captopril group (P < 0.05). The total estimated direct and indirect cost of HTN is very high all over the world. [...]it is important to be diagnosed in early stages and also to be controlled.11-14 An important situation in patients with high BP is hypertensive crisis which is characterized by a severe elevation in BP to the degree which is life-threatening (> 180/120 mmHg)6>15>16 with or without end organ damage and requires immediate management.16 Hypertensive emergency is accompanied by acute or ongoing end organ damage, while hypertensive urgency is not associated with any evidence of end organ damage.6'1618 Previous studies have implied that urgency is more prevalent. [...]here, we decided to compare the effect of captopril and clonidine in patients with hypertensive urgencies, and their side effects. [...]group received oral clonidine 0.1-0.2 mg, followed by 0.05-0.1 mg every 1 to 2 hours, to the maximum dose of 0.6-0.7 mg.
ISSN:1735-3955
2251-6638
DOI:10.22122/arya.v18i0.2146