Physicochemical and biological characterization of oxidized multi-walled carbon nanotubes on HepG2 liver cells

Functionalization of multi-walled carbon nanotubes (MWCNTs) is a growing area in the field of materials with biological applications; due that their surface characteristics could determine their biocompatibility and therapeutic uses. This research is focused on the evaluation of the effect of oxidiz...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2022-07, Vol.24 (7), Article 151
Main Authors: Uribe-Calderon, Jorge A., Poot-Bote, Cielo G., Cervantes-Uc, José M., Pacheco-Pantoja, Elda L., Echevarría-Machado, Ileana, Rodríguez-Fuentes, Nayeli
Format: Article
Language:English
Subjects:
Biocompatibility
Biological effects
Biological properties
Cancer
Carbon
Cell viability
Characterization and Evaluation of Materials
Chemistry and Materials Science
Cytotoxicity
Genotoxicity
Hepatocytes
Hydrogen peroxide
Inorganic Chemistry
Lasers
Liver cancer
Materials Science
Multi wall carbon nanotubes
Nanoparticles
Nanotechnology
Nanotubes
Nitric acid
Optical Devices
Optics
Oxidation
Oxidation process
Photonics
Physical Chemistry
Physicochemical properties
Research Paper
Sulfuric acid
Surface properties
Toxicity
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Summary:Functionalization of multi-walled carbon nanotubes (MWCNTs) is a growing area in the field of materials with biological applications; due that their surface characteristics could determine their biocompatibility and therapeutic uses. This research is focused on the evaluation of the effect of oxidized MWCNTs on the cell cultures of a hepatic carcinoma cell line (HepG2). Pristine MWCNTs (p-MWCNT) with an external diameter of 8–15 nm and a length in the range of 10–50 μm were oxidized with (a) nitric acid/hydrogen peroxide, (b) nitric acid, and (c) nitric acid/sulfuric acid solutions, and their physicochemical properties and biological effects were examined. The findings demonstrated that MWCNT oxidation produced different surface moieties and structural changes depending on the oxidation process, in particular, the oxidation with nitric acid/sulfuric acid generates a high grade of cell toxicity compared to the other types of oxidized MWCNTs. Interestingly, the p-MWCNTs exhibited slight cytotoxic and genotoxic effects but without affecting cell viability, which requires further analysis. The results open the possibility of using oxidized MWCNT with nitric acid/sulfuric acid to promote cytotoxic effects on cancer cells, as well as to explore different oxidative methods in medical applications.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-022-05489-1