Rare earth-based MOF@mesoporous silica nanoplatform for long-term and luminescence trackable chemotherapy

Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging assignment. In this task, we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy, which is prepared via a hollow ZIF-8 (where ZIF is zeolitic imidazol...

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Bibliographic Details
Published in:Rare metals 2022-08, Vol.41 (8), p.2701-2710
Main Authors: Wang, Lu-Min, Liu, Wen-Yan, Hu, Ming-Liang, Yao, Jia-Sai, Wang, Ping, Liu, Jia-Hao, He, Miao, Gao, Yi, Li, Zhen-Xing
Format: Article
Language:English
Subjects:
Biomaterials
Chemistry and Materials Science
Chemotherapy
Doxorubicin
Drugs
Energy
Europium
Luminescence
Materials Engineering
Materials Science
Metal-organic frameworks
Metallic Materials
Nanoscale Science and Technology
Original Article
Physical Chemistry
Silicon dioxide
Tin
Tumors
Zeolites
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Summary:Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging assignment. In this task, we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy, which is prepared via a hollow ZIF-8 (where ZIF is zeolitic imidazolate frameworks) coated by the Eu 3+ -doped mesoporous silica (ZIF-8@mesoporous silica). The hollow ZIF-8 is used as a drug library for loading the anticancer drug, and the pH-sensitive properties of ZIF-8 can targeted-release drugs in the tumor and cut down the poisonousness of drugs to normal cells. The shell layer of mesoporous silica can achieve the long-term drug release, which solves the problem of short drug circulation time in the body, reduces the drug administration frequency, and improves the therapeutic effect. Notably, the ZIF-8@mesoporous + doxorubicin (DOX) is injected only once during the 14-day chemotherapy. In addition, Eu 3+ - doped in mesoporous silica ensures luminescence tracking and detection of drug pathways in living cells. Hence, this nanoplatform provides a whole new strategy for the long-term treatment of tumors. Graphical abstract
ISSN:1001-0521
1867-7185
DOI:10.1007/s12598-022-01978-3