Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice

• Published in: IEEE transactions on neural systems and rehabilitation engineering 2022, Vol.30, p.1-1
• Main Authors: Pang, Na, Meng, Wen, Zhong, Yongsheng, Liu, Xiufang, Lin, Zhengrong, Guo, Tianxu, Zhou, Hui, Qi, Lin, Meng, Long, Xu, Lisheng, Niu, Lili
• Format: Article
• Language: English
• Subjects: Acoustics; Alzheimer's disease; Body temperature; Brain; Brain stimulation; Deep brain stimulation; Health services; Hyperthermia; Hypothalamus; Hypothalamus (anterior); Hypothalamus (dorsomedial); Hypothermia; Malignant hyperthermia; Mice; Movement disorders; Neurodegenerative diseases; Neuromodulation; Noninvasive ultrasound; Parkinson's disease; Preoptic area; Pulse repetition frequency; Rehabilitation; Sensorimotor system; Stimulation; Temperature measurement; Temperature sensors; Thermoregulation; Time-frequency analysis; Ultrasonic imaging; Ultrasound
• ISSN: 1534-4320; 1558-0210
• DOI: 10.1109/TNSRE.2022.3188516

Body temperature plays a critical role in rehabilitation, and numerous studies proved that the regulation of body temperature contributes to the sensorimotor recovery of patients with brain diseases such as stroke. The hypothalamus plays a key role in thermoregulation. Ultrasound deep brain stimulation (UDBS) can noninvasively modulate deep brain nuclei and have potential applications in the treatment of Parkinson's disease, Alzheimer's disease, and depression, among others. The purpose of this study was to investigate whether ultrasound stimulation of the hypothalamus could regulate body temperature in free-moving mice. Results showed that thermoregulation was related to ultrasonic parameters (pulse repetition frequency (PRF), duty cycle, total time, and acoustic pressure). UDBS of the preoptic area of the anterior hypothalamus at 500 Hz PRF could significantly reduce body temperature (ΔT = -0.25 ± 0.073 °C at t = 5 min, ΔT = -0.51 ± 0.19 °C at t = 10 min, ΔT = -0.84 ± 0.27 °C at t = 15 min). Meanwhile, UDBS of the dorsomedial hypothalamus at 10 Hz PRF triggered a significant increase in body temperature (ΔT = 0.5 ± 0.077 °C at t = 5 min, ΔT = 1.16 ± 0.23 °C at t = 10 min). These results suggest that UDBS, as a noninvasive neuromodulation tool, may play a key role in the future clinical treatment of malignant hyperthermia and hypothermia.