Nano-encapsulation of polyphenols in starch nanoparticles: fabrication, characterization and evaluation

Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols. Our study aimed to use catechin (CC), epicatechin (EC) and proanthocyanidin (PAC) adsorp...

Full description

Saved in:
Bibliographic Details
Published in:Food & function 2022-07, Vol.13 (14), p.7762-7771
Main Authors: Lian, Fengli, Gong, Ersheng, Liang, Hanni, Lin, Yanyun, Chen, Jun, He, Yunxia, Hebelstrup, Kim Henrik, Xia, Wen
Format: Article
Language:English
Subjects:
Adsorption
Antioxidants
Bioavailability
Catechin
Cytotoxicity
Drug carriers
Drug delivery
Epicatechin
Epithelial cells
Epithelium
Fabrication
Free radicals
Intestine
Isotherms
Microcapsules
Microencapsulation
Nanoparticles
Polyphenols
Starch
Tapioca
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols. Our study aimed to use catechin (CC), epicatechin (EC) and proanthocyanidin (PAC) adsorption onto tapioca starch nanoparticles (TSNs), which were prepared by a physical method. These TSN loaded-polyphenols were subjected to adsorption kinetic, adsorption isotherm, adsorption capacity, antioxidant activity, and in vitro release analyses. The maximum adsorption capacities of TSNs for CC, EC and PACs were 179.39 mg g −1 , 109.29 mg g −1 and 287.19 mg g −1 , respectively. The adsorption dynamics and isotherms of polyphenols on TSNs conformed well to the pseudo-second-order kinetics and the Freundlich isotherms. Moreover, TSN loaded-polyphenols have low cytotoxicity and can continuously be released under stimulated gastric and intestinal conditions. Antioxidant activity tests showed that TSN loaded-polyphenols can remarkably scavenge DPPH free radicals; the IC 50 of TSNs-CC, TSNs-EC and TSNs-PAC were 16.11, 16.59 and 16.93 μg mL −1 , respectively. Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols.
ISSN:2042-6496
2042-650X
DOI:10.1039/d1fo04197e