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Nano-encapsulation of polyphenols in starch nanoparticles: fabrication, characterization and evaluation
Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols. Our study aimed to use catechin (CC), epicatechin (EC) and proanthocyanidin (PAC) adsorp...
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| Published in: | Food & function 2022-07, Vol.13 (14), p.7762-7771 |
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| Main Authors: | , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c314t-b963a05799d7e6be972de5b51c4238883ec08ad3b721cb308c2785de38f121543 |
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| cites | cdi_FETCH-LOGICAL-c314t-b963a05799d7e6be972de5b51c4238883ec08ad3b721cb308c2785de38f121543 |
| container_end_page | 7771 |
| container_issue | 14 |
| container_start_page | 7762 |
| container_title | Food & function |
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| creator | Lian, Fengli Gong, Ersheng Liang, Hanni Lin, Yanyun Chen, Jun He, Yunxia Hebelstrup, Kim Henrik Xia, Wen |
| description | Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols. Our study aimed to use catechin (CC), epicatechin (EC) and proanthocyanidin (PAC) adsorption onto tapioca starch nanoparticles (TSNs), which were prepared by a physical method. These TSN loaded-polyphenols were subjected to adsorption kinetic, adsorption isotherm, adsorption capacity, antioxidant activity, and
in vitro
release analyses. The maximum adsorption capacities of TSNs for CC, EC and PACs were 179.39 mg g
−1
, 109.29 mg g
−1
and 287.19 mg g
−1
, respectively. The adsorption dynamics and isotherms of polyphenols on TSNs conformed well to the pseudo-second-order kinetics and the Freundlich isotherms. Moreover, TSN loaded-polyphenols have low cytotoxicity and can continuously be released under stimulated gastric and intestinal conditions. Antioxidant activity tests showed that TSN loaded-polyphenols can remarkably scavenge DPPH free radicals; the IC
50
of TSNs-CC, TSNs-EC and TSNs-PAC were 16.11, 16.59 and 16.93 μg mL
−1
, respectively.
Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols. |
| doi_str_mv | 10.1039/d1fo04197e |
| format | article |
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in vitro
release analyses. The maximum adsorption capacities of TSNs for CC, EC and PACs were 179.39 mg g
−1
, 109.29 mg g
−1
and 287.19 mg g
−1
, respectively. The adsorption dynamics and isotherms of polyphenols on TSNs conformed well to the pseudo-second-order kinetics and the Freundlich isotherms. Moreover, TSN loaded-polyphenols have low cytotoxicity and can continuously be released under stimulated gastric and intestinal conditions. Antioxidant activity tests showed that TSN loaded-polyphenols can remarkably scavenge DPPH free radicals; the IC
50
of TSNs-CC, TSNs-EC and TSNs-PAC were 16.11, 16.59 and 16.93 μg mL
−1
, respectively.
Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo04197e</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Adsorption ; Antioxidants ; Bioavailability ; Catechin ; Cytotoxicity ; Drug carriers ; Drug delivery ; Epicatechin ; Epithelial cells ; Epithelium ; Fabrication ; Free radicals ; Intestine ; Isotherms ; Microcapsules ; Microencapsulation ; Nanoparticles ; Polyphenols ; Starch ; Tapioca ; Toxicity</subject><ispartof>Food & function, 2022-07, Vol.13 (14), p.7762-7771</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-b963a05799d7e6be972de5b51c4238883ec08ad3b721cb308c2785de38f121543</citedby><cites>FETCH-LOGICAL-c314t-b963a05799d7e6be972de5b51c4238883ec08ad3b721cb308c2785de38f121543</cites><orcidid>0000-0003-3090-5540 ; 0000-0001-7654-7430</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Lian, Fengli</creatorcontrib><creatorcontrib>Gong, Ersheng</creatorcontrib><creatorcontrib>Liang, Hanni</creatorcontrib><creatorcontrib>Lin, Yanyun</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>He, Yunxia</creatorcontrib><creatorcontrib>Hebelstrup, Kim Henrik</creatorcontrib><creatorcontrib>Xia, Wen</creatorcontrib><title>Nano-encapsulation of polyphenols in starch nanoparticles: fabrication, characterization and evaluation</title><title>Food & function</title><description>Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols. Our study aimed to use catechin (CC), epicatechin (EC) and proanthocyanidin (PAC) adsorption onto tapioca starch nanoparticles (TSNs), which were prepared by a physical method. These TSN loaded-polyphenols were subjected to adsorption kinetic, adsorption isotherm, adsorption capacity, antioxidant activity, and
in vitro
release analyses. The maximum adsorption capacities of TSNs for CC, EC and PACs were 179.39 mg g
−1
, 109.29 mg g
−1
and 287.19 mg g
−1
, respectively. The adsorption dynamics and isotherms of polyphenols on TSNs conformed well to the pseudo-second-order kinetics and the Freundlich isotherms. Moreover, TSN loaded-polyphenols have low cytotoxicity and can continuously be released under stimulated gastric and intestinal conditions. Antioxidant activity tests showed that TSN loaded-polyphenols can remarkably scavenge DPPH free radicals; the IC
50
of TSNs-CC, TSNs-EC and TSNs-PAC were 16.11, 16.59 and 16.93 μg mL
−1
, respectively.
Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols.</description><subject>Adsorption</subject><subject>Antioxidants</subject><subject>Bioavailability</subject><subject>Catechin</subject><subject>Cytotoxicity</subject><subject>Drug carriers</subject><subject>Drug delivery</subject><subject>Epicatechin</subject><subject>Epithelial cells</subject><subject>Epithelium</subject><subject>Fabrication</subject><subject>Free radicals</subject><subject>Intestine</subject><subject>Isotherms</subject><subject>Microcapsules</subject><subject>Microencapsulation</subject><subject>Nanoparticles</subject><subject>Polyphenols</subject><subject>Starch</subject><subject>Tapioca</subject><subject>Toxicity</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpd0UtLAzEQAOAgCpbai3ch4EXE1Tz2kXiT2qpQ7EXB25LNztotabImu0L99a5bH2Auk4FvhmEGoWNKLinh8qqklSMxlRnsoREjMYvShLzs__xjmR6iSQhr0j8upZBihF4flXURWK2a0BnV1s5iV-HGmW2zAutMwLXFoVVer7DtbaN8W2sD4RpXqvC1HmousF4pr3QLvv7YdVG2xPCuTDekR-igUibA5DuO0fN89jS9jxbLu4fpzSLSnMZtVMiUK5JkUpYZpAXIjJWQFAnVMeNCCA6aCFXyImNUF5wIzTKRlMBFRRlNYj5GZ7u-jXdvHYQ239RBgzHKgutCzlLBWErkQE__0bXrvO2n65WkRGRJynt1vlPauxA8VHnj643y25yS_Gvt-S2dL4e1z3p8ssM-6F_3dxb-CRZCf6c</recordid><startdate>20220718</startdate><enddate>20220718</enddate><creator>Lian, Fengli</creator><creator>Gong, Ersheng</creator><creator>Liang, Hanni</creator><creator>Lin, Yanyun</creator><creator>Chen, Jun</creator><creator>He, Yunxia</creator><creator>Hebelstrup, Kim Henrik</creator><creator>Xia, Wen</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3090-5540</orcidid><orcidid>https://orcid.org/0000-0001-7654-7430</orcidid></search><sort><creationdate>20220718</creationdate><title>Nano-encapsulation of polyphenols in starch nanoparticles: fabrication, characterization and evaluation</title><author>Lian, Fengli ; Gong, Ersheng ; Liang, Hanni ; Lin, Yanyun ; Chen, Jun ; He, Yunxia ; Hebelstrup, Kim Henrik ; Xia, Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-b963a05799d7e6be972de5b51c4238883ec08ad3b721cb308c2785de38f121543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adsorption</topic><topic>Antioxidants</topic><topic>Bioavailability</topic><topic>Catechin</topic><topic>Cytotoxicity</topic><topic>Drug carriers</topic><topic>Drug delivery</topic><topic>Epicatechin</topic><topic>Epithelial cells</topic><topic>Epithelium</topic><topic>Fabrication</topic><topic>Free radicals</topic><topic>Intestine</topic><topic>Isotherms</topic><topic>Microcapsules</topic><topic>Microencapsulation</topic><topic>Nanoparticles</topic><topic>Polyphenols</topic><topic>Starch</topic><topic>Tapioca</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lian, Fengli</creatorcontrib><creatorcontrib>Gong, Ersheng</creatorcontrib><creatorcontrib>Liang, Hanni</creatorcontrib><creatorcontrib>Lin, Yanyun</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>He, Yunxia</creatorcontrib><creatorcontrib>Hebelstrup, Kim Henrik</creatorcontrib><creatorcontrib>Xia, Wen</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lian, Fengli</au><au>Gong, Ersheng</au><au>Liang, Hanni</au><au>Lin, Yanyun</au><au>Chen, Jun</au><au>He, Yunxia</au><au>Hebelstrup, Kim Henrik</au><au>Xia, Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nano-encapsulation of polyphenols in starch nanoparticles: fabrication, characterization and evaluation</atitle><jtitle>Food & function</jtitle><date>2022-07-18</date><risdate>2022</risdate><volume>13</volume><issue>14</issue><spage>7762</spage><epage>7771</epage><pages>7762-7771</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols. Our study aimed to use catechin (CC), epicatechin (EC) and proanthocyanidin (PAC) adsorption onto tapioca starch nanoparticles (TSNs), which were prepared by a physical method. These TSN loaded-polyphenols were subjected to adsorption kinetic, adsorption isotherm, adsorption capacity, antioxidant activity, and
in vitro
release analyses. The maximum adsorption capacities of TSNs for CC, EC and PACs were 179.39 mg g
−1
, 109.29 mg g
−1
and 287.19 mg g
−1
, respectively. The adsorption dynamics and isotherms of polyphenols on TSNs conformed well to the pseudo-second-order kinetics and the Freundlich isotherms. Moreover, TSN loaded-polyphenols have low cytotoxicity and can continuously be released under stimulated gastric and intestinal conditions. Antioxidant activity tests showed that TSN loaded-polyphenols can remarkably scavenge DPPH free radicals; the IC
50
of TSNs-CC, TSNs-EC and TSNs-PAC were 16.11, 16.59 and 16.93 μg mL
−1
, respectively.
Nanoparticles are more promising than microcapsules as drug carriers because they can be absorbed directly by intestinal epithelial cells, significantly increasing the uptake and bioaccessibility of polyphenols.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d1fo04197e</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3090-5540</orcidid><orcidid>https://orcid.org/0000-0001-7654-7430</orcidid></addata></record> |
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| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2022-07, Vol.13 (14), p.7762-7771 |
| issn | 2042-6496 2042-650X |
| language | eng |
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| source | Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list) |
| subjects | Adsorption Antioxidants Bioavailability Catechin Cytotoxicity Drug carriers Drug delivery Epicatechin Epithelial cells Epithelium Fabrication Free radicals Intestine Isotherms Microcapsules Microencapsulation Nanoparticles Polyphenols Starch Tapioca Toxicity |
| title | Nano-encapsulation of polyphenols in starch nanoparticles: fabrication, characterization and evaluation |
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