Biflavonoids from the twigs and leaves of Cephalotaxus oliveri Mast. and their α-glucosidase inhibitory activity

Three new biflavonoids, umcephabiovins C − E (1 − 3), along with fourteen known compounds were isolated from the twigs and leaves of Cephalotaxus oliveri. Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds 1 − 3 exhibited significant α-glucosida...

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Bibliographic Details
Published in:Natural product research 2022-06, Vol.36 (12), p.3085-3094
Main Authors: Song, Min, Xiao, Tong, Wu, Qiu-Shuang, Kwok, Hang Fai, Chan, Ging, Lin, Li-Gen, Zhang, Xiao-Qi, Ye, Wen-Cai, He, Sheng-Jiang, Zhang, Qing-Wen
Format: Article
Language:English
Subjects:
biflavonoids
Cephalotaxus
Cephalotaxus oliveri
Cytotoxicity
Glucosidase
NMR
Nuclear magnetic resonance
Toxicity
α-Glucosidase
α-glucosidase inhibitory activity
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Summary:Three new biflavonoids, umcephabiovins C − E (1 − 3), along with fourteen known compounds were isolated from the twigs and leaves of Cephalotaxus oliveri. Their structures and configurations were elucidated by UV, IR, NMR, ECD, and HR-ESI-MS spectra. Compounds 1 − 3 exhibited significant α-glucosidase inhibitory activity with IC 50 values of 7.05 ± 2.66, 24.45 ± 4.73, and 1.84 ± 1.14 μM, respectively. Compound 11 showed moderate cytotoxicity against the BaF3/T315I cell line.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1958328