Expression analysis of MINA53: correlation with aberrantly expressed mRNAs and pathological features in non-small lung cancer

The present study investigated the expression signature of the MINA53 gene in 50 lung adenocarcinoma (LUAD) and 50 squamous cell lung carcinoma (LUSC) tumors and their adjacent non-tumor tissues via RT-qPCR. Association analysis was performed to explore the correlation between the levels of the MINA...

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Bibliographic Details
Published in:Biotechnology, biotechnological equipment biotechnological equipment, 2021-01, Vol.35 (1), p.1791-1798
Main Authors: Petkova, Veronika, Marinova, Dora, Kyurkchiyan, Silva, Stancheva, Gergana, Mekov, Evgeni, Kachakova-Yordanova, Darina, Slavova, Yanina, Kostadinov, Dimitar, Mitev, Vanyo, Kaneva, Radka
Format: Article
Language:English
Subjects:
Adenocarcinoma
Association analysis
Biomarkers
Carcinogenesis
Carcinogens
Epidermal growth factor receptors
Gene expression
LUAD
Lung cancer
Lung carcinoma
LUSC
Lymph nodes
Metastases
MINA53
Non-small cell lung carcinoma
NSCLC
PD-L1 protein
PTEN protein
Regression analysis
Squamous cell carcinoma
Stat3 protein
TOR protein
Tumors
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Summary:The present study investigated the expression signature of the MINA53 gene in 50 lung adenocarcinoma (LUAD) and 50 squamous cell lung carcinoma (LUSC) tumors and their adjacent non-tumor tissues via RT-qPCR. Association analysis was performed to explore the correlation between the levels of the MINA53 and the clinicopathological characteristics of the patients. The MINA53 gene expression was upregulated in early-stage tumors with poor tumor differentiation, without lymph nodes and distant metastases. To explore the potential role of MINA53 in carcinogenesis, we evaluated the expression pattern of five known lung cancer-associated genes: EGFR, mTOR, PTEN, STAT3 and PD-L1. The regression analysis showed a correlation between MINA53 expression and EGFR in LUAD and PD-L1 and STAT3 in LUSC. This suggests a distant oncogenic role of MINA53 in both subtypes of NSCLC and opens up the potential for development of new therapeutic strategies and the potential role of MINA53 as a prognostic and predictive biomarker.
ISSN:1310-2818
1314-3530
DOI:10.1080/13102818.2021.2019117