Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses

The purpose of this article was to assess the existing systematic reviews and meta-analyses for the association between vitamin C intake and multiple health outcomes. A total of 76 meta-analyses (51 papers) of randomised controlled trials and observational studies with 63 unique health outcomes were...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2022-08, Vol.73 (5), p.588-599
Main Authors: Xu, Kedi, Peng, Rui, Zou, Yuanlin, Jiang, Xiaoru, Sun, Qiuyu, Song, Chunhua
Format: Article
Language:English
Subjects:
Ascorbic Acid
Breast cancer
Calculi
Cardiovascular diseases
Cardiovascular Diseases - prevention & control
Cervical cancer
Cervix
Dietary Supplements
Food science
Gastric cancer
health
Heart diseases
Humans
Literature reviews
Lung cancer
Meta-analysis
Meta-Analysis as Topic
Nephrolithiasis
Nutrition
Nutritional Status
Observational studies
Risk management
Systematic review
Systematic Reviews as Topic
umbrella review
Vitamin C
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Summary:The purpose of this article was to assess the existing systematic reviews and meta-analyses for the association between vitamin C intake and multiple health outcomes. A total of 76 meta-analyses (51 papers) of randomised controlled trials and observational studies with 63 unique health outcomes were identified. Dose-response analysis showed that vitamin C intake was associated with reduced risk of all-cause mortality, cardiovascular disease (CVD), oesophageal cancer, gastric cancer, cervical cancer and lung cancer with an increment of 50-100 mg per day. Beneficial associations were also identified for respiratory, neurological, ophthalmologic, musculoskeletal, renal and dental outcomes. Harmful associations were found for breast cancer and kidney stones for vitamin C supplement intake. The benefits of vitamin C intake outweigh the disadvantages for a range of health outcomes. However, the recommendation of vitamin C supplements needs to be cautious. More prospective studies and well-designed randomised controlled trials (RCTs) are needed.
ISSN:0963-7486
1465-3478
1465-3478
DOI:10.1080/09637486.2022.2048359