Surface functionalization of 3D printed Ti scaffold with Zn-containing mesoporous bioactive glass

• Published in: Surface & coatings technology 2022-04, Vol.435, p.128236, Article 128236
• Main Authors: Chen, Qian, Zhao, Xueyang, Lai, Weiji, Li, Zheng, You, Deqiang, Yu, Zhentao, Li, Wei, Wang, Xiaojian
• Format: Article
• Language: English
• Subjects: 3D printing; Antibacterial materials; Apatite; Biocompatibility; Bioglass; Biological activity; Bone infection; Coatings; Implants; Mesoporous bioactive glasses coating; Scaffolds; Three dimensional printing; Titanium; Zinc
• ISSN: 0257-8972; 1879-3347
• DOI: 10.1016/j.surfcoat.2022.128236

Implants-associated infections affect millions of people worldwide and are becoming increasingly challenging clinically. Intensive research efforts have been dedicated to developing novel antibacterial coatings for porous metallic implants with complex topological structures. In this work, Zn doped bactericidal mesoporous bioactive glass (MBG) coatings were developed on 3D printed Ti scaffolds. With the content of Zn increased from 1 mol% to 5 mol%, the specific surface area of the MBG coatings declined from 377.6 m2/g to 174.5 m2/g, leading to a decreased apatite inducing ability. However, antibacterial studies revealed that the addition of zinc improved the antibacterial properties significantly. MC3T3-E1 cells were used to evaluate the cyto-biocompatibility of the coatings. It was found that scaffolds coated with MBG and 1Zn MBG coatings promoted cells proliferation and exhibited good cyto-compatibilities. •Zn-doped bactericidal MBG coating was applied to 3D printed Ti scaffold with complex structure.•With the increase of Zn, the samples showed increased antibacterial ability.•1 mol% Zn doping promoted cyto-compatibilities and showed good antibacterial properties.