Metformin administration during pregnancy — current insight

The main mechanism of gestational diabetes mellitus (GDM) is insulin resistance, therefore using metformin as a medicinereducing insulin resistance appears to be promising.Currently, the majority of medical associations do not recommend using metformin during pregnancy as the first-line oftherapy wh...

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Bibliographic Details
Published in:Ginekologia polska 2021-01, Vol.92 (1), p.46-50
Main Authors: Skibinska, Milena, Zurawska- Klis, Monika, Krekora, Michal, Cypryk, Katarzyna
Format: Article
Language:English
Subjects:
Antidiabetics
Body mass index
Gestational diabetes
Glucose
Hospitals
Hypoglycemia
Insulin resistance
Obstetrics
Polycystic ovary syndrome
Preeclampsia
Pregnancy
Womens health
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Summary:The main mechanism of gestational diabetes mellitus (GDM) is insulin resistance, therefore using metformin as a medicinereducing insulin resistance appears to be promising.Currently, the majority of medical associations do not recommend using metformin during pregnancy as the first-line oftherapy when the diet regimen is insufficient for glycaemic control. However, they do allow its administration if there isno possibility of insulin treatment.There is some evidence which suggests that using metformin during pregnancy is not related to an increased risk of obstetriccomplications during delivery and that its influence on the foetus can be beneficial.Since metformin crosses the placenta, the major argument for cautious use of this drug are the potential long-term effectsof the treatment for the child and its development in later life.In this article, the authors attempt to discuss the use of metformin during pregnancy and the safety of the treatment inthe light of current studies and recommendations.
ISSN:0017-0011
2543-6767
DOI:10.5603/GP.a2020.0149