Electrochemical sensing of copper-chelator D- penicillamine based on complexation with gold nanoparticles modified copper based-metal organic frameworks

• Published in: Journal of electroanalytical chemistry (Lausanne, Switzerland) Switzerland), 2022-03, Vol.908, p.116102, Article 116102
• Main Authors: Alkahtani, Saad A., Mahmoud, Ashraf M., El-Wekil, Mohamed M.
• Format: Article
• Language: English
• Subjects: Copper; Copper based-metal organic frameworks; Copper-pencillamine complex; d-Pencillamine; Electron microscopes; Fourier transforms; Glassy carbon; Gold; Gold nanoparticles; Infrared spectroscopy; Metal-organic frameworks; Nanocomposites; Nanoparticles; Spectrum analysis; Square wave voltammetry; Square waves; Thermogravimetry; X-ray spectroscopy
• ISSN: 1572-6657; 1873-2569
• DOI: 10.1016/j.jelechem.2022.116102

[Display omitted] •AuNPs@Cu-MOF was synthesized by a facile method.•It shows a good electro-catalytic activity towards D-PA determination.•D-PA is detected by the formation of complex at low potential.•The modified sensor shows wide linear range and low LOD.•The sensor was efficiently applied for capsules, plasma and urine samples. Copper based-metal organic frameworks modified with gold nanoparticles (AuNPs@Cu-MOF) was fabricated via facile approach. The nanocomposite was used to decorate glassy carbon electrode (GCE) for the electrochemical sensing of D- penicillamine (D-PA). The nanocomposite was characterized using different techniques such as scanning electron microscope (SEM), transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDX), powder X-ray spectroscopy (PXRD), thermogravimetry (TGA), nitrogen adsorption–desorption isotherms, and Fourier Transform infrared spectroscopy (FTIR). Formation of a new anodic peak of Cu(II)-D-PA complex at + 0.38 V was used to detect D-PA. Cyclic and square wave voltammetric studies proved that AuNPs elevated the conductivity of Cu-MOF. The sensor exhibited wide linear range (0.4–75 × 10−7 M) and low detection limit (0.11 × 10−7 M) with a good sensitivity (0.9 ± 0.01 μA/μM). It was successfully applied for the estimation of D-PA in different real samples with recoveries % and relative standard deviations % (RSDs %) in the range of 95.6–102.5% and 2.4–3.3%, respectively.