Implementation of sonicated continuous plug flow crystallization technology for processing of acetylsalicylic acid reaction mixture

An effective way to ensure proper mixing and thereby realize maintenance-free operation of the clogging-sensitive continuous tubular crystallizers is the utilization of ultrasound-irradiation. Considering this, our research aimed to develop an ultrasonicated plug flow crystallization process to sepa...

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Bibliographic Details
Published in:Powder technology 2022-03, Vol.400, p.117255, Article 117255
Main Authors: Tacsi, Kornélia, Stoffán, György, Pusztai, Éva, Nagy, Brigitta, Domokos, András, Szilágyi, Botond, Nagy, Zsombor Kristóf, Marosi, György, Pataki, Hajnalka
Format: Article
Language:English
Subjects:
Acetylsalicylic acid
Continuous crystallization
Crystallization
Crystallizers
Design of experiments
Experimental design
Feeding rates
Irradiation
Mixtures
Parameter modification
Plug flow
Plug flow crystallizer
Plugs
Process parameters
Product quality
Radiation
Residence time distribution
Size distribution
Sonocrystallization
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Summary:An effective way to ensure proper mixing and thereby realize maintenance-free operation of the clogging-sensitive continuous tubular crystallizers is the utilization of ultrasound-irradiation. Considering this, our research aimed to develop an ultrasonicated plug flow crystallization process to separate and purify a multicomponent acetylsalicylic acid (ASA) flow reaction mixture with antisolvent and combined cooling-antisolvent method. The influence of process parameters – temperature, antisolvent to ASA solution ratio, mean residence time – on purity, yield, productivity, product size, and size distribution was investigated applying a 23 full factorial experimental design. In further analysis, the alteration of product quality and quantity was studied by reducing the ultrasonicated tubing length and increasing the feeding rate, which could be important for industrial applicability. It was found that ultrasonication results in robustness against process parameter modification regarding product quality producing purified, small (
ISSN:0032-5910
1873-328X
DOI:10.1016/j.powtec.2022.117255