Bergenin from Bergenia Species Produces a Protective Response against Myocardial Infarction in Rats

Bergenin is a phenolic glycoside that has been reported to occur naturally in several plant species, reported as a cardioprotective. However, bergenin, one of the important phytochemicals in these plants, is still not reported as a cardioprotective. The present study was designed to investigate the...

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Published in:Processes 2022-07, Vol.10 (7), p.1403
Main Authors: Ahmad, Taseer, Haq, Imran Ul, Khan, Taous, Mahnashi, Mater H., Alasmary, Mohammed Y., Almedhesh, Sultan A., Shehri, Hamdan Al, Alshahrani, Mohammed A., Shah, Abdul Jabbar
Format: Article
Language:English
Subjects:
Atenolol
Biomarkers
Edema
EKG
Enzymes
Glycosides
Heart
Heart attacks
Inflammation
Ischemia
Isoproterenol
Markers
Myocardial infarction
Phenolic compounds
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Summary:Bergenin is a phenolic glycoside that has been reported to occur naturally in several plant species, reported as a cardioprotective. However, bergenin, one of the important phytochemicals in these plants, is still not reported as a cardioprotective. The present study was designed to investigate the cardioprotective effects of bergenin on isoproterenol-induced myocardial infarction in rats. Bergenin and atenolol were administered through intraperitoneal (i.p.) injection to Sprague Dawley (SD) rats in separate experiments for five (5) days. At the end of this period, rats were administered isoproterenol (80 mg/kg s.c.) to induce myocardial injury. After induction, rats were anaesthetized to record lead II ECG, then sacrificed, blood was collected to analyze cardiac marker enzymes, and a histopathological study of the heart tissues was also performed. Pretreatment with bergenin showed a significant decrease in ST-segment elevation, deep Q-wave, infarct size, and also normalized cardiac marker enzymes (cTnI, CPK, CK-MB, LDH, ALT, and AST), particularly at 3 mg/kg, as compared to isoproterenol treated group. Our findings revealed, for the first time, the use of glycoside bergenin as a potential cardioprotective agent against the isoproterenol-induced MI in rats.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr10071403