Green Synthesis of a Novel Silver Nanoparticle Conjugated with Thelypteris glandulosolanosa (Raqui-Raqui): Preliminary Characterization and Anticancer Activity

In the last decade, the green synthesis of nanoparticles has had a prominent role in scientific research for industrial and biomedical applications. In this current study, silver nitrate (AgNO3) was reduced and stabilized with an aqueous extract of Thelypteris glandulosolanosa (Raqui-raqui), forming...

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Bibliographic Details
Published in:Processes 2022-07, Vol.10 (7), p.1308
Main Authors: Vera-Nuñez, Lucero Del Carmen, Cornejo-Ruiz, Junior Oliver, Arenas-Chávez, Carlos Alberto, de Hollanda, Luciana Maria, Alvarez-Risco, Aldo, Del-Aguila-Arcentales, Shyla, Davies, Neal M., Yáñez, Jaime A., Vera-Gonzales, Corina
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor activity
Biocompatibility
Biomedical materials
Breast cancer
Cancer therapies
Cell death
Chemotherapy
Connective tissues
Contact angle
Cytotoxicity
Gold
Light scattering
Lung cancer
Lung carcinoma
Mammary gland
Mammary glands
Metabolites
Nanocomposites
Nanoparticles
Photon correlation spectroscopy
Scanning transmission electron microscopy
Scratch resistance
Silver
Silver nitrate
Size distribution
Spectrophotometry
Synthesis
Thelypteris
Toxicity
Transmission electron microscopy
Wear resistance
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Summary:In the last decade, the green synthesis of nanoparticles has had a prominent role in scientific research for industrial and biomedical applications. In this current study, silver nitrate (AgNO3) was reduced and stabilized with an aqueous extract of Thelypteris glandulosolanosa (Raqui-raqui), forming silver nanoparticles (AgNPs-RR). UV-vis spectrophotometry, dynamic light scattering (DLS), and scanning transmission electron microscopy (STEM) were utilized to analyze the structures of AgNPs-RR. The results from this analysis showed a characteristic peak at 420 nm and a mean hydrodynamic size equal to 39.16 nm, while the STEM revealed a size distribution of 6.64–51.00 nm with an average diameter of 31.45 nm. Cellular cytotoxicity assays using MCF-7 (ATCC® HTB-22™, mammary gland breast), A549 (ATCC® CCL-185, lung epithelial carcinoma), and L929 (ATCC® CCL-1, subcutaneous connective tissue of Mus musculus) demonstrated over 42.70% of MCF-7, 59.24% of A549, and 8.80% of L929 cells had cell death after 48 h showing that this nanoparticle is more selective to disrupt neoplastic than non-cancerous cells and may be further developed into an effective strategy for breast and lung cancer treatment. These results demonstrate that the nanoparticle surfaces developed are complex, have lower contact angles, and have excellent scratch and wear resistance.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr10071308