Genome sequences of chikungunya virus isolates from an outbreak in southwest Bangkok in 2018

An outbreak of chikungunya virus (CHIKV) infection occurred in southwest Bangkok during the 2018 rainy season. The envelope glycoprotein E1 gene sequence of the infecting strain belonged to an East/Central/South African lineage with alanine at residue 226. Mutations in the predicted E1 (K211E) and E...

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Bibliographic Details
Published in:Archives of virology 2020-02, Vol.165 (2), p.445-450
Main Authors: Chansaenroj, Jira, Wanlapakorn, Nasamon, Ngamsaithong, Chokchai, Thongmee, Thanunrat, Na nakorn, Natthaphon, Siriyasatien, Padet, Vongpunsawad, Sompong, Poovorawan, Yong
Format: Article
Language:English
Subjects:
Aedes - virology
Aedes aegypti
Alanine
Animals
Base Sequence
Biomedical and Life Sciences
Biomedicine
Brief Report
Chikungunya Fever - virology
Chikungunya virus
Chikungunya virus - genetics
Chikungunya virus - isolation & purification
Disease Outbreaks
E1 gene
Epidemics
Female
Gene amplification
Genome, Viral - genetics
Genomes
Glycoprotein E1
Glycoproteins
Humans
Infections
Infectious Diseases
Medical Microbiology
Mosquito Vectors - virology
Mosquitoes
Mutation
Mutation - genetics
Outbreaks
Patients
Phylogenetics
Phylogeny
RNA, Viral - genetics
Sequence Analysis, DNA - methods
Strains (organisms)
Thailand
Viral Envelope Proteins - genetics
Virology
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Description
Summary:An outbreak of chikungunya virus (CHIKV) infection occurred in southwest Bangkok during the 2018 rainy season. The envelope glycoprotein E1 gene sequence of the infecting strain belonged to an East/Central/South African lineage with alanine at residue 226. Mutations in the predicted E1 (K211E) and E2 (V264A) proteins of CHIKV were identified in CHIKV-infected patients and in an Aedes aegypti mosquito. Analysis of the complete genome sequences showed marked differences from the strains causing previous outbreaks in Thailand in 2008-2009 and 2013 but showed similarities to strains from more recent CHIKV outbreaks in South and Southeast Asia.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-019-04509-1