Side effects of TNF-α blockers in patients with psoriatic arthritis: evidences from literature studies

Psoriatic arthritis is an inflammatory rheumatic disorder, which occurs in patients with skin and/or nail psoriasis. In psoriatic arthritis, the importance of biologic mediators modulating inflammatory reaction, such as tumor necrosis factor, and the knowledge on their role in the pathogenesis of ps...

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Bibliographic Details
Published in:Clinical rheumatology 2013-06, Vol.32 (6), p.743-753
Main Authors: Peluso, Rosario, Cafaro, Giovanni, Di Minno, Alessandro, Iervolino, Salvatore, Ambrosino, Pasquale, Lupoli, Gelsy, Di Minno, Matteo Nicola Dario
Format: Article
Language:English
Subjects:
Antirheumatic Agents - adverse effects
Antirheumatic Agents - therapeutic use
Arthritis
Arthritis, Psoriatic - complications
Arthritis, Psoriatic - drug therapy
Autoimmune Diseases - chemically induced
Body Weight - drug effects
Cardiovascular Diseases - chemically induced
Female
Humans
Male
Medicine
Medicine & Public Health
Neoplasms - chemically induced
Nervous System Diseases - chemically induced
Patients
Pregnancy
Pregnancy Complications - chemically induced
Psoriasis
Psoriatic arthritis
Respiratory Tract Diseases - chemically induced
Review Article
Rheumatology
Side effects
Skin - drug effects
Skin Diseases - complications
Skin Diseases - therapy
Treatment Outcome
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor necrosis factor-α
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Summary:Psoriatic arthritis is an inflammatory rheumatic disorder, which occurs in patients with skin and/or nail psoriasis. In psoriatic arthritis, the importance of biologic mediators modulating inflammatory reaction, such as tumor necrosis factor, and the knowledge on their role in the pathogenesis of psoriatic arthritis influence the therapeutic choices. In the last years, the introduction of biologic drugs has greatly changed the treatment of psoriasis and psoriatic arthritis. In fact, tumor necrosis factor-α blockers demonstrated an effective action in the treatment of both skin and joint manifestations of psoriatic arthritis, but they have some adverse effects. The aim of this review is to revisit the literature data on adverse effects of tumor necrosis factor-α blockers in patients with psoriatic arthritis.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-013-2252-0