A dual-emission ratiometric fluorescence capillary imprinted sensor based on metal-organic frameworks for sensitive detection of L-tyrosine

• Published in: Sensors and actuators. B, Chemical Chemical, 2022-09, Vol.367, p.132058, Article 132058
• Main Authors: Tang, Sisi, Zhao, Pengfei, Wu, Xiaodan, Chen, Yu, Tang, Kangling, Zhou, Shu, Fu, Jinli, Lei, Huibin, Yang, Zhaoxia, Zhang, Zhaohui
• Format: Article
• Language: English
• Subjects: Capillary; Chiral recognition; Emission; Fluorescence; Imprinted; L-tyrosine; Luminescence; Metal-organic frameworks; Quantum dots; Ratiometric fluorescence; Reagents; Reference signals; Selectivity; Sensors; Tyrosine
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/j.snb.2022.132058

A novel dual-emission ratiometric fluorescence capillary imprinted sensor based on luminescence metal organic framework was fabricated firstly with high sensitivity and selectivity for chiral recognition of L-tyrosine. To construct the ratiometric fluorescence capillary imprinted sensor, the luminescence metal organic framework and near-infrared quantum dots silicon as fluorescence sources were embedded into the imprinted layer which was grown up on the inner surface of amino-modified capillary. In present of L-tyrosine, the blue fluorescence (424 nm) served as fluorescence response signal was quenched due to the inner filter effects between metal organic framework and L-tyrosine while the red fluorescence (688 nm) served as the reference signal was remained. With the linear range of 1.0 × 10−10~ 2.5 × 10−8 M, the ratiometric fluorescence capillary imprinted sensor was applied to detect L-tyrosine in actual sample successfully with the satisfactory recoveries of 99.07~101.18% and the detect limitation of 8.0 × 10−11 M, indicating great potential application for detecting L-tyrosine in actual samples. The sensor integrated the molecularly imprinted technology and fluorescence capillary method achieved sensitive and selective determination of L-tyrosine with micro volume reagent consumption (18 μl) which provided a route for trace detection. •A novel dual-emission ratiometric fluorescence capillary imprinted sensor was prepared.•The fluorescence sensor has high sensitivity due to amplification of fluorescence signal of capillary waveguide effect.•The fluorescence sensor realized micro-volume sample analysis (18 μl) for L- tyrosine.•The fluorescence sensor was selective for chiral recognition of L- tyrosine.