Antimicrobial activity and cytotoxicity effect of the prepared bioactive Ag-NPs using Senna alata leaf extract on MCF-7 cancer cell line and brine shrimp

The leaf extract of Senna alata (SA) was employed as a bio-reducing agent to prepare the bioactive Ag-NPs. The FTIR spectrum of Ag-NPs revealed the existence of biomolecules in SA leaf extract. The formation of Ag-NPs was confirmed by analyzing their XRD profile. The SPR band at 434 nm in the UV spe...

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Bibliographic Details
Published in:Journal of sol-gel science and technology 2022-09, Vol.103 (3), p.766-776
Main Authors: Saravanan, A., Parthasarathy, V., Kumar, P. Senthil
Format: Article
Language:English
Subjects:
Anticancer properties
Antiinfectives and antibacterials
Antimicrobial agents
Biocompatibility
Biological activity
Biomolecules
Brines
Cancer
Ceramics
Chemistry and Materials Science
Cholera
Composites
Cytotoxicity
Glass
Grain size
Inorganic Chemistry
Leaves
Materials Science
Nanotechnology
Natural Materials
Optical and Electronic Materials
Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
Reducing agents
Toxicity testing
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Summary:The leaf extract of Senna alata (SA) was employed as a bio-reducing agent to prepare the bioactive Ag-NPs. The FTIR spectrum of Ag-NPs revealed the existence of biomolecules in SA leaf extract. The formation of Ag-NPs was confirmed by analyzing their XRD profile. The SPR band at 434 nm in the UV spectrum also supported the formation of Ag-NPs. The grain size was computed as 25 nm by XRD. It was further confirmed using TEM. The morphology of the bioactive Ag-NPs was affirmed as spherical by SEM. The cytotoxicity of bioactive Ag-NPs against brine shrimp was assessed by a lethal toxicity test. The significant antibacterial potential of bioactive Ag-NPs against six pathogenic strains was concluded by disc diffusion assay. The prepared bioactive Ag-NPs exhibited a higher antimicrobial property against B. subtilis and V. cholera . The anticancer property of the prepared Ag-NPs was also examined against breast cancer cells. Graphical abstract Highlights The bioactive Ag-NPs were prepared by using leaf extract of Senna alata . The bioactive Ag-NPs exhibited significant antimicrobial activity against six pathogenic strains. The anticancer potential of bioactive Ag-NPs was also examined against the MCF-7 cell line.
ISSN:0928-0707
1573-4846
DOI:10.1007/s10971-022-05889-8