Design and Synthesis, In Silico Analysis of Condensed Pyrimidine derivatives as Potent Antimicrobial Agents

A series of 24 condensed pyrimidine derivatives was synthesized via multistep reactions using microwave radiation and have opted to explore the possible inhibition mechanism via virtual analysis by using V life MDS. The synthesized compounds were characterized by spectroscopic analysis. All the synt...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2022-06, Vol.15 (6), p.2422-2426
Main Authors: Khedkar, S. A., Patil, J. S., Sabale, P. M.
Format: Article
Language:English
Subjects:
Analgesics
Anti-inflammatory agents
Antibiotics
Antimicrobial agents
Bacteria
Design
E coli
Hydrogen bonds
Proteins
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Summary:A series of 24 condensed pyrimidine derivatives was synthesized via multistep reactions using microwave radiation and have opted to explore the possible inhibition mechanism via virtual analysis by using V life MDS. The synthesized compounds were characterized by spectroscopic analysis. All the synthesized compounds were found to show good in-silico binding analysis which indicated their potential to explore as good antimicrobial agents. All the synthesized derivatives were screened in-vitro for their antibacterial activity against two gram positive and gram negative bacteria. Among the compounds tested, SAKB2, SAKB7, SAKB8, SAKB9 SAKB10, SAKB11, SAKB12 and SAKB13derivatives exhibited potent antimicrobial activity.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2022.00403