Development and Validation of a Solvent Extraction UV Spectrophotometric Method for the Estimation of Rosuvastatin Calcium and Telmisartan in Combined Dosage Form

A simple, precise, accurate and reproducible method has been developed and validated for the estimation of Telmisartan and Rosuvastatin Calcium in their combined tablet dosage form using solvent extraction method followed by UV spectrophotometry. The absorbance was measured at 243.8nm and 295.3nm fo...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2022-05, Vol.15 (5), p.2065-2069
Main Authors: Jose, Elseena, C. Nair, Anjana, Kuttichan, Merlin, Govind A, Vishnu
Format: Article
Language:English
Subjects:
Accuracy
Cardiovascular disease
Drug dosages
Laboratories
Solvent extraction processes
Standard deviation
Statins
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Summary:A simple, precise, accurate and reproducible method has been developed and validated for the estimation of Telmisartan and Rosuvastatin Calcium in their combined tablet dosage form using solvent extraction method followed by UV spectrophotometry. The absorbance was measured at 243.8nm and 295.3nm for Rosuvastatin and Telmisartan respectively. Linearity was found over the concentration range 5-25 micro gram per ml. The solvents used for the estimation were methanol for Telmisartan and phosphate buffer for Rosuvastatin. The method was statistically validated for accuracy, precision, linearity, LOD and LOQ according to ICH guidelines and can be used for analysis of combined dosage form as well as for the individual drugs.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2022.00341