A Dual‐Bioinspired Tissue Adhesive Based on Peptide Dendrimer with Fast and Strong Wet Adhesion

• Published in: Advanced healthcare materials 2022-08, Vol.11 (15), p.e2200874-n/a
• Main Authors: Zhu, Haofang, Xu, Guoming, He, Yiyan, Mao, Hongli, Kong, Deling, Luo, Kui, Tang, Wenbo, Liu, Rong, Gu, Zhongwei
• Format: Article
• Language: English
• Subjects: Adhesion; Adhesive strength; Adhesives; Adhesives - pharmacology; Animals; Bonding strength; Carboxymethyl cellulose; Carboxymethylcellulose; Catechol; Cellulose; Chitosan; Dendrimers; Glues; Hemostasis; Hemostatics; Hydrogels; In vivo methods and tests; Interfacial bonding; Lysine; Mechanical properties; peptide dendrimers; Peptides; Polysaccharides; Rabbits; Swine; Tissue Adhesions; tissue adhesives; Tissue Adhesives - pharmacology; Tissues; Trauma; wet adhesion; Wound healing
• ISSN: 2192-2640; 2192-2659
• DOI: 10.1002/adhm.202200874

Although tissue adhesives have potential advantages over traditional sutures, existing ones suffer from several limitations: slow adhesion kinetic, low mechanical strength, and poor interfacial bonding with wet biological tissues. Herein, a cooperative mussel/slug double‐bioinspired hydrogel adhesive (DBHA) composed of a robust adhesive interface and a stretchable dissipative matrix is developed. The DBHA is formed by a cationic polysaccharide (chitosan), an anionic polysaccharide (carboxymethyl cellulose), and a barbell‐like dendritic lysine grafted with catechol groups (G3KPCA). Compared to various commercial bio‐glues and traditional adhesives, the DBHA has significantly stronger tissue adhesion and enhanced toughness both ex vivo and in vivo. Meanwhile, the DBHA exhibits fast, strong, tough, and durable adhesion to diverse ex vivo tissue surfaces with blood. The adhesion energy between the adhesive and porcine skin can reach 200–900 J m−2. Additionally, in vivo studies prove that DBHA has good hemostasis of rabbit artery trauma and achieves better wound healing of tissue incision than commercial bio‐glues. This study provides a novel strategy for fabricating fast and strong wet adhesives, which can be used in many applications, such as soft robots, tissue adhesives and hemostats. A cooperative mussel/slug double‐bioinspired hydrogel adhesive (DBHA) with promising wet adhesion performance under biological conditions is developed. The DBHA enhances toughness and exhibits fast, strong, and durable adhesion to various tissue surfaces with blood. Additionally, DBHA achieves better hemostasis and wound closure of artery trauma than commercial bio‐glues in vivo, enabling its great potential in various biomedical applications.