Controlled compositions of tellurium/vanadium co-doped into hydroxyapatite/ε-polycaprolactone for wound healing applications

Hydroxyapatite (HAP) was co-doped with tellurium and vanadium ions via the co-precipitation method. Pure HAP nanoparticles were embedded through polymeric materials, such as polycaprolactone (PCL), to improve and upgrade their functionality. The PCL/HAP scaffold nanofiber has been successfully prepa...

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Bibliographic Details
Published in:New journal of chemistry 2022-08, Vol.46 (31), p.14816-14825
Main Authors: Alsenany, Nourah, Mansour, S. F., Eldera, Samah S.
Format: Article
Language:English
Subjects:
Contact angle
Hydroxyapatite
Mechanical properties
Nanofibers
Nanoparticles
Polycaprolactone
Scaffolds
Surface roughness
Tellurium
Tensile strength
Vanadium
Wound healing
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Summary:Hydroxyapatite (HAP) was co-doped with tellurium and vanadium ions via the co-precipitation method. Pure HAP nanoparticles were embedded through polymeric materials, such as polycaprolactone (PCL), to improve and upgrade their functionality. The PCL/HAP scaffold nanofiber has been successfully prepared using the electrospinning method and analyzed including nanostructure, surface roughness, and tensile strength. The roughness increased from 37.6 to 71.4 nm through a powdered phase, while it developed from 54.1 to 114.4 nm for the nanofibrous membranes. Furthermore, the mechanical behavior has been studied and showed a progression upon the addition of Te ions from 7.45 ± 0.8 to 10.38 ± 1.4 MPa in tensile strength. The contact angle was measured. It was reduced, indicating the modification of hydrophilicity of pristine PCL. The angle values decreased from 105.4 to 88.5° within the nanofibrous scaffolds. The scaffolds were cultured with the fibroblast cell line for three days, whereas the cells proliferated and grew through the scaffolds considerably.
ISSN:1144-0546
1369-9261
DOI:10.1039/D2NJ00760F