The Role of Myeloid-Derived Suppressor Cells in Establishing Immune Tolerance during Pregnancy

Myeloid-derived suppressor cells (MDSCs) are a cell population involved in the regulation of immune response by means by inhibiting it in pathologies, as well as during pregnancy. This review summarizes the available data on the effect of MDSCs on different components of innate and adaptive immunity...

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Bibliographic Details
Published in:Cell and tissue biology 2022-08, Vol.16 (4), p.330-338
Main Authors: Shardina, K. Yu, Zamorina, S. A., Raev, M. B., Chereshnev, V. A.
Format: Article
Language:English
Subjects:
Adaptive immunity
Biomedical and Life Sciences
Cell Biology
Cord blood
Immune response
Immune status
Immunological tolerance
Life Sciences
Preeclampsia
Pregnancy
Suppressor cells
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Summary:Myeloid-derived suppressor cells (MDSCs) are a cell population involved in the regulation of immune response by means by inhibiting it in pathologies, as well as during pregnancy. This review summarizes the available data on the effect of MDSCs on different components of innate and adaptive immunity, taking into account the different ways in which their immunosuppressive functions are carried out. Analysis of current studies on the mechanisms of suppression of the MDSC immune response are presented, and an assessment is given of the role of MDSCs in maintaince of immune tolerance during pregnancy. Data on MDSCs in various pathological conditions during pregnancy and the content of MDSCs in umbilical-cord blood weree[amined, and the relationship between these cells and the immune status was reviewed.
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X22040071