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Separation of monodisperse poly(3-hydroxybutyrate) particles by fractionation: Theory and practice
A new method is proposed in this article which is based on fractionation and results poly(3-hydroxybutyrate) particles of nearly monodisperse size distribution. This kind of separation is achieved by taking advantage of the phenomenon that the movement of particles triggered by a constant force in a...
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Published in: | Powder technology 2022-05, Vol.403, p.117383, Article 117383 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | A new method is proposed in this article which is based on fractionation and results poly(3-hydroxybutyrate) particles of nearly monodisperse size distribution. This kind of separation is achieved by taking advantage of the phenomenon that the movement of particles triggered by a constant force in a homogeneous fluid have a velocity depending on the diameter of the particle. The procedure consists of two steps. First, a set of particles with a wide distribution of diameters is produced by using the emulsion-suspension method followed by their separation into fractions on hydrogel columns in the second step. The novel concept of statistical filters has been introduced in order to describe this phenomenon quantitatively. Additionally, mathematical models have been developed that allow the simulation and prediction of the outcome of particle separation. Our method was verified by model calculations and measurements; the results of the two approaches correlated closely. The proposed method is very advantageous for the preparation of drug carrier matrices, because it allows the close control and modeling of the kinetics of drug release.
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•Particle fractionation allows the preparation of monodisperse PHB particles.•The separation is done on hydrogel columns.•The novel concept of statistical filter has been introduced for theoretical description.•The efficiency of the separation can be characterized quantitatively. |
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ISSN: | 0032-5910 1873-328X |
DOI: | 10.1016/j.powtec.2022.117383 |